Detailed information of TA system TA046874

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2060244..2060543
• Replicon: chromosome
• Accession: NZ_CP007676
• Organism: Staphylococcus aureus strain HUV05

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: ER12_RS15390
• Protein ID: WP_011447039.1
• Coordinates: 2060367..2060543 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2060244..2060299 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ER12_RS10375	2055575..2055835	+	261	WP_001791826.1	hypothetical protein	-
ER12_RS10380	2055888..2056238	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
ER12_RS10385	2056923..2057372	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
ER12_RS15805	2057467..2057802	-	336	Protein_1962	SH3 domain-containing protein	-
ER12_RS10395	2058452..2058943	-	492	WP_000919350.1	staphylokinase	-
ER12_RS10400	2059134..2059889	-	756	WP_000861038.1	CHAP domain-containing protein	-
ER12_RS10405	2059901..2060155	-	255	WP_000611512.1	phage holin	-
ER12_RS10410	2060207..2060314	+	108	WP_001791821.1	hypothetical protein	-
-	2060236..2060375	+	140	NuclAT_0	-	-
-	2060236..2060375	+	140	NuclAT_0	-	-
-	2060236..2060375	+	140	NuclAT_0	-	-
-	2060236..2060375	+	140	NuclAT_0	-	-
-	2060244..2060299	+	56	-	-	Antitoxin
ER12_RS15390	2060367..2060543	-	177	WP_011447039.1	putative holin-like toxin	Toxin
ER12_RS10415	2060693..2060989	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
ER12_RS10420	2061047..2061334	-	288	WP_001040261.1	hypothetical protein	-
ER12_RS10425	2061381..2061533	-	153	WP_001153681.1	hypothetical protein	-
ER12_RS10430	2061523..2065308	-	3786	WP_048520783.1	phage minor structural protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2055888..2114855	58967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T46874 WP_011447039.1 NZ_CP007676:c2060543-2060367 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T46874 NZ_CP007676:c2060543-2060367 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT46874 NZ_CP007676:2060244-2060299 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin