Detailed information of TA system TA046858

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2056300..2056599
• Replicon: chromosome
• Accession: NZ_CP007674
• Organism: Staphylococcus aureus strain CA15

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: EQ90_RS15940
• Protein ID: WP_011447039.1
• Coordinates: 2056423..2056599 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2056300..2056355 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQ90_RS15915	2051631..2051891	+	261	WP_001791826.1	hypothetical protein	-
EQ90_RS10355	2051944..2052294	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
EQ90_RS10360	2052979..2053428	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
EQ90_RS16615	2053523..2053858	-	336	Protein_1961	SH3 domain-containing protein	-
EQ90_RS10370	2054508..2054999	-	492	WP_000919350.1	staphylokinase	-
EQ90_RS10375	2055190..2055945	-	756	WP_000861038.1	CHAP domain-containing protein	-
EQ90_RS10380	2055957..2056211	-	255	WP_000611512.1	phage holin	-
EQ90_RS15935	2056263..2056370	+	108	WP_001791821.1	hypothetical protein	-
-	2056292..2056431	+	140	NuclAT_0	-	-
-	2056292..2056431	+	140	NuclAT_0	-	-
-	2056292..2056431	+	140	NuclAT_0	-	-
-	2056292..2056431	+	140	NuclAT_0	-	-
-	2056300..2056355	+	56	-	-	Antitoxin
EQ90_RS15940	2056423..2056599	-	177	WP_011447039.1	putative holin-like toxin	Toxin
EQ90_RS10395	2056749..2057045	-	297	WP_047339384.1	DUF2951 domain-containing protein	-
EQ90_RS10400	2057103..2057390	-	288	WP_001040261.1	hypothetical protein	-
EQ90_RS15945	2057437..2057589	-	153	WP_001153681.1	hypothetical protein	-
EQ90_RS10410	2057579..2061364	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2051944..2107893	55949

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T46858 WP_011447039.1 NZ_CP007674:c2056599-2056423 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T46858 NZ_CP007674:c2056599-2056423 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT46858 NZ_CP007674:2056300-2056355 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin