Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2524304..2524488 Replicon chromosome
Accession NZ_CP007672
Organism Staphylococcus aureus strain CA12

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag EQ80_RS12990 Protein ID WP_000482650.1
Coordinates 2524381..2524488 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2524304..2524364 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQ80_RS12965 2519833..2520000 - 168 WP_001790576.1 hypothetical protein -
EQ80_RS12975 2520231..2521964 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
EQ80_RS12980 2521989..2523753 - 1765 Protein_2451 ABC transporter ATP-binding protein -
- 2524304..2524364 + 61 - - Antitoxin
EQ80_RS12990 2524381..2524488 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
EQ80_RS12995 2524622..2525008 - 387 WP_000779358.1 flippase GtxA -
EQ80_RS13000 2525276..2526418 + 1143 WP_001176863.1 glycerate kinase -
EQ80_RS13005 2526478..2527137 + 660 WP_000831298.1 membrane protein -
EQ80_RS13010 2527319..2528530 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
EQ80_RS13015 2528653..2529126 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T46851 WP_000482650.1 NZ_CP007672:c2524488-2524381 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T46851 NZ_CP007672:c2524488-2524381 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT46851 NZ_CP007672:2524304-2524364 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References