Detailed information of TA system TA046842

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2059573..2059872
• Replicon: chromosome
• Accession: NZ_CP007672
• Organism: Staphylococcus aureus strain CA12

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: EQ80_RS15160
• Protein ID: WP_011447039.1
• Coordinates: 2059696..2059872 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2059573..2059628 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQ80_RS10380	2054904..2055164	+	261	WP_001791826.1	hypothetical protein	-
EQ80_RS10385	2055217..2055567	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
EQ80_RS10390	2056252..2056701	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
EQ80_RS15490	2056796..2057131	-	336	Protein_1959	SH3 domain-containing protein	-
EQ80_RS10400	2057781..2058272	-	492	WP_000919350.1	staphylokinase	-
EQ80_RS10405	2058463..2059218	-	756	WP_000861038.1	CHAP domain-containing protein	-
EQ80_RS10410	2059230..2059484	-	255	WP_000611512.1	phage holin	-
EQ80_RS10415	2059536..2059643	+	108	WP_001791821.1	hypothetical protein	-
-	2059565..2059704	+	140	NuclAT_0	-	-
-	2059565..2059704	+	140	NuclAT_0	-	-
-	2059565..2059704	+	140	NuclAT_0	-	-
-	2059565..2059704	+	140	NuclAT_0	-	-
-	2059573..2059628	+	56	-	-	Antitoxin
EQ80_RS15160	2059696..2059872	-	177	WP_011447039.1	putative holin-like toxin	Toxin
EQ80_RS10420	2060022..2060318	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
EQ80_RS10425	2060376..2060663	-	288	WP_001040261.1	hypothetical protein	-
EQ80_RS10430	2060710..2060862	-	153	WP_001153681.1	hypothetical protein	-
EQ80_RS10435	2060852..2064637	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2055217..2111165	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T46842 WP_011447039.1 NZ_CP007672:c2059872-2059696 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T46842 NZ_CP007672:c2059872-2059696 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT46842 NZ_CP007672:2059573-2059628 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin