46835

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2580258..2580442 Replicon chromosome
Accession NZ_CP007670
Organism Staphylococcus aureus strain M121

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag EP54_RS16660 Protein ID WP_000482650.1
Coordinates 2580335..2580442 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2580258..2580318 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP54_RS16640 2575788..2575955 - 168 WP_001790576.1 hypothetical protein -
EP54_RS13415 2576186..2577919 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
EP54_RS13420 2577944..2579707 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2580258..2580318 + 61 - - Antitoxin
EP54_RS16660 2580335..2580442 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
EP54_RS13435 2580576..2580962 - 387 WP_000779358.1 flippase GtxA -
EP54_RS13440 2581230..2582372 + 1143 WP_001176863.1 glycerate kinase -
EP54_RS13445 2582432..2583091 + 660 WP_000831298.1 membrane protein -
EP54_RS13450 2583273..2584484 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
EP54_RS13455 2584607..2585080 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T46835 WP_000482650.1 NZ_CP007670:c2580442-2580335 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T46835 NZ_CP007670:c2580442-2580335 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT46835 NZ_CP007670:2580258-2580318 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References