46834

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2554910..2555427 Replicon chromosome
Accession NZ_CP007670
Organism Staphylococcus aureus strain M121

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag EP54_RS13275 Protein ID WP_000113262.1
Coordinates 2554910..2555176 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag EP54_RS13280 Protein ID WP_000584499.1
Coordinates 2555176..2555427 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP54_RS13250 2550336..2550872 - 537 WP_000169316.1 GNAT family N-acetyltransferase -
EP54_RS13255 2551105..2551929 - 825 WP_000572040.1 formate/nitrite transporter family protein -
EP54_RS13260 2552146..2552328 - 183 WP_000230294.1 hypothetical protein -
EP54_RS13265 2552412..2552879 - 468 WP_000153344.1 SRPBCC domain-containing protein -
EP54_RS13270 2553065..2554615 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EP54_RS17050 2554804..2554875 - 72 Protein_2511 hypothetical protein -
EP54_RS13275 2554910..2555176 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
EP54_RS13280 2555176..2555427 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EP54_RS16610 2555592..2555693 - 102 WP_001791744.1 hypothetical protein -
EP54_RS13290 2555700..2556299 - 600 WP_000162813.1 DsbA family protein -
EP54_RS13295 2556318..2556677 - 360 WP_000819847.1 DUF4467 domain-containing protein -
EP54_RS13300 2556932..2558182 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
EP54_RS13305 2558279..2559010 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
EP54_RS13310 2559007..2559726 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T46834 WP_000113262.1 NZ_CP007670:c2555176-2554910 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T46834 NZ_CP007670:c2555176-2554910 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT46834 WP_000584499.1 NZ_CP007670:c2555427-2555176 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT46834 NZ_CP007670:c2555427-2555176 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References