Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2290202..2290419 Replicon chromosome
Accession NZ_CP007670
Organism Staphylococcus aureus strain M121

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag EP54_RS16460 Protein ID WP_001802298.1
Coordinates 2290315..2290419 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2290202..2290257 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP54_RS11840 2286339..2287004 - 666 WP_001024094.1 SDR family oxidoreductase -
EP54_RS11845 2287156..2287476 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
EP54_RS11850 2287478..2288458 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
EP54_RS11855 2288724..2289815 + 1092 WP_000495671.1 lytic regulatory protein -
- 2290202..2290257 + 56 - - Antitoxin
EP54_RS16460 2290315..2290419 - 105 WP_001802298.1 hypothetical protein Toxin
EP54_RS17040 2290580..2291063 - 484 Protein_2245 recombinase family protein -
EP54_RS11870 2291106..2292242 - 1137 WP_000115564.1 SAP domain-containing protein -
EP54_RS16465 2292531..2292623 + 93 WP_001790138.1 hypothetical protein -
EP54_RS11880 2293328..2294185 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
EP54_RS11885 2294253..2295035 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T46833 WP_001802298.1 NZ_CP007670:c2290419-2290315 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T46833 NZ_CP007670:c2290419-2290315 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT46833 NZ_CP007670:2290202-2290257 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References