Detailed information of TA system TA046826

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2115534..2115833
• Replicon: chromosome
• Accession: NZ_CP007670
• Organism: Staphylococcus aureus strain M121

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: EP54_RS16350
• Protein ID: WP_011447039.1
• Coordinates: 2115657..2115833 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2115534..2115589 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EP54_RS16325	2110865..2111125	+	261	WP_001791826.1	hypothetical protein	-
EP54_RS10815	2111178..2111528	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
EP54_RS10820	2112213..2112662	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
EP54_RS17035	2112757..2113092	-	336	Protein_2047	SH3 domain-containing protein	-
EP54_RS10830	2113742..2114233	-	492	Protein_2048	staphylokinase	-
EP54_RS10835	2114424..2115179	-	756	WP_000861038.1	CHAP domain-containing protein	-
EP54_RS10840	2115191..2115445	-	255	WP_000611512.1	phage holin	-
EP54_RS16345	2115497..2115604	+	108	WP_001791821.1	hypothetical protein	-
-	2115526..2115665	+	140	NuclAT_0	-	-
-	2115526..2115665	+	140	NuclAT_0	-	-
-	2115526..2115665	+	140	NuclAT_0	-	-
-	2115526..2115665	+	140	NuclAT_0	-	-
-	2115534..2115589	+	56	-	-	Antitoxin
EP54_RS16350	2115657..2115833	-	177	WP_011447039.1	putative holin-like toxin	Toxin
EP54_RS10855	2115983..2116279	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
EP54_RS10860	2116337..2116624	-	288	WP_001040261.1	hypothetical protein	-
EP54_RS16355	2116671..2116823	-	153	WP_001153681.1	hypothetical protein	-
EP54_RS10870	2116813..2120598	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / sak / hlb / groEL	2111178..2167125	55947

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T46826 WP_011447039.1 NZ_CP007670:c2115833-2115657 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T46826 NZ_CP007670:c2115833-2115657 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT46826 NZ_CP007670:2115534-2115589 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin