Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2528870..2529054 Replicon chromosome
Accession NZ_CP007659
Organism Staphylococcus aureus strain H-EMRSA-15

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag ER16_RS12895 Protein ID WP_000482647.1
Coordinates 2528947..2529054 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2528870..2528930 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER16_RS12880 2524666..2526399 - 1734 WP_000486501.1 ABC transporter ATP-binding protein/permease -
ER16_RS12885 2526424..2528187 - 1764 WP_001064811.1 ABC transporter ATP-binding protein/permease -
- 2528870..2528930 + 61 - - Antitoxin
ER16_RS12895 2528947..2529054 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
ER16_RS12900 2529188..2529574 - 387 WP_000779356.1 flippase GtxA -
ER16_RS12905 2529842..2530984 + 1143 WP_001176863.1 glycerate kinase -
ER16_RS12910 2531044..2531703 + 660 WP_000831298.1 membrane protein -
ER16_RS12915 2531882..2533093 + 1212 WP_001191976.1 multidrug effflux MFS transporter -
ER16_RS12920 2533216..2533689 - 474 WP_000456498.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T46812 WP_000482647.1 NZ_CP007659:c2529054-2528947 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T46812 NZ_CP007659:c2529054-2528947 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT46812 NZ_CP007659:2528870-2528930 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References