Detailed information of TA system TA046811

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2502157..2502674
• Replicon: chromosome
• Accession: NZ_CP007659
• Organism: Staphylococcus aureus strain H-EMRSA-15

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: ER16_RS12735
• Protein ID: WP_000113261.1
• Coordinates: 2502157..2502423 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: ER16_RS12740
• Protein ID: WP_000584499.1
• Coordinates: 2502423..2502674 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ER16_RS12710	2497594..2498130	-	537	WP_000169319.1	GNAT family N-acetyltransferase	-
ER16_RS12715	2498364..2499188	-	825	WP_000594637.1	formate/nitrite transporter family protein	-
ER16_RS12720	2499391..2499573	-	183	WP_000250735.1	hypothetical protein	-
ER16_RS12725	2499660..2500127	-	468	WP_000153345.1	SRPBCC domain-containing protein	-
ER16_RS12730	2500313..2501863	-	1551	WP_000727760.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
ER16_RS12735	2502157..2502423	-	267	WP_000113261.1	Txe/YoeB family addiction module toxin	Toxin
ER16_RS12740	2502423..2502674	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ER16_RS12745	2502837..2502938	-	102	Protein_2415	hypothetical protein	-
ER16_RS12750	2502945..2503544	-	600	WP_000162810.1	DsbA family protein	-
ER16_RS12755	2503563..2503925	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
ER16_RS12760	2504180..2505430	+	1251	WP_001012231.1	FemA/FemB family glycyltransferase FmhA	-
ER16_RS12765	2505515..2506246	-	732	WP_000615455.1	amino acid ABC transporter ATP-binding protein	-
ER16_RS12770	2506243..2506962	-	720	WP_000479573.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10452.02 Da
• Isoelectric Point: 10.0373

>T46811 WP_000113261.1 NZ_CP007659:c2502423-2502157 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T46811 NZ_CP007659:c2502423-2502157 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAAGCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT46811 WP_000584499.1 NZ_CP007659:c2502674-2502423 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT46811 NZ_CP007659:c2502674-2502423 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAGCACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Antitoxin

• AlphaFold DB: T1YB60