Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2502157..2502674 Replicon chromosome
Accession NZ_CP007659
Organism Staphylococcus aureus strain H-EMRSA-15

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag ER16_RS12735 Protein ID WP_000113261.1
Coordinates 2502157..2502423 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag ER16_RS12740 Protein ID WP_000584499.1
Coordinates 2502423..2502674 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER16_RS12710 2497594..2498130 - 537 WP_000169319.1 GNAT family N-acetyltransferase -
ER16_RS12715 2498364..2499188 - 825 WP_000594637.1 formate/nitrite transporter family protein -
ER16_RS12720 2499391..2499573 - 183 WP_000250735.1 hypothetical protein -
ER16_RS12725 2499660..2500127 - 468 WP_000153345.1 SRPBCC domain-containing protein -
ER16_RS12730 2500313..2501863 - 1551 WP_000727760.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ER16_RS12735 2502157..2502423 - 267 WP_000113261.1 Txe/YoeB family addiction module toxin Toxin
ER16_RS12740 2502423..2502674 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ER16_RS12745 2502837..2502938 - 102 Protein_2415 hypothetical protein -
ER16_RS12750 2502945..2503544 - 600 WP_000162810.1 DsbA family protein -
ER16_RS12755 2503563..2503925 - 363 WP_000819843.1 DUF4467 domain-containing protein -
ER16_RS12760 2504180..2505430 + 1251 WP_001012231.1 FemA/FemB family glycyltransferase FmhA -
ER16_RS12765 2505515..2506246 - 732 WP_000615455.1 amino acid ABC transporter ATP-binding protein -
ER16_RS12770 2506243..2506962 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10452.02 Da        Isoelectric Point: 10.0373

>T46811 WP_000113261.1 NZ_CP007659:c2502423-2502157 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY

Download         Length: 267 bp

>T46811 NZ_CP007659:c2502423-2502157 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAAGCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT46811 WP_000584499.1 NZ_CP007659:c2502674-2502423 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT46811 NZ_CP007659:c2502674-2502423 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAGCACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References