Detailed information of TA system TA046806

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF2/-
• Location: 2062512..2062811
• Replicon: chromosome
• Accession: NZ_CP007659
• Organism: Staphylococcus aureus strain H-EMRSA-15

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: ER16_RS14950
• Protein ID: WP_011447039.1
• Coordinates: 2062635..2062811 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2062512..2062567 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ER16_RS10315	2057843..2058103	+	261	WP_001791826.1	hypothetical protein	-
ER16_RS10320	2058156..2058506	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
ER16_RS10325	2059191..2059640	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
ER16_RS15330	2059735..2060070	-	336	Protein_1948	SH3 domain-containing protein	-
ER16_RS10335	2060720..2061211	-	492	WP_000919349.1	staphylokinase	-
ER16_RS10340	2061402..2062157	-	756	WP_000861038.1	CHAP domain-containing protein	-
ER16_RS10345	2062169..2062423	-	255	WP_000611512.1	phage holin	-
ER16_RS14945	2062475..2062582	+	108	WP_001791821.1	hypothetical protein	-
-	2062504..2062643	+	140	NuclAT_1	-	-
-	2062504..2062643	+	140	NuclAT_1	-	-
-	2062504..2062643	+	140	NuclAT_1	-	-
-	2062504..2062643	+	140	NuclAT_1	-	-
-	2062512..2062567	+	56	-	-	Antitoxin
ER16_RS14950	2062635..2062811	-	177	WP_011447039.1	putative holin-like toxin	Toxin
ER16_RS10355	2062961..2063257	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
ER16_RS10360	2063315..2063602	-	288	WP_001040261.1	hypothetical protein	-
ER16_RS10365	2063649..2063801	-	153	WP_001153681.1	hypothetical protein	-
ER16_RS10370	2063791..2067576	-	3786	WP_000582168.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2058156..2116076	57920

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T46806 WP_011447039.1 NZ_CP007659:c2062811-2062635 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T46806 NZ_CP007659:c2062811-2062635 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT46806 NZ_CP007659:2062512-2062567 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin