Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1909644..1909824 Replicon chromosome
Accession NZ_CP007659
Organism Staphylococcus aureus strain H-EMRSA-15

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag ER16_RS15305 Protein ID WP_001801861.1
Coordinates 1909644..1909739 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1909767..1909824 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER16_RS09340 1904931..1905698 - 768 WP_001095317.1 IS21-like element helper ATPase IstB -
ER16_RS09345 1905710..1906945 - 1236 WP_001215400.1 IS21 family transposase -
ER16_RS09350 1907303..1907872 - 570 WP_000864144.1 ImmA/IrrE family metallo-endopeptidase -
ER16_RS09360 1908245..1908421 - 177 WP_000375476.1 hypothetical protein -
ER16_RS09365 1908432..1908815 - 384 WP_000070809.1 hypothetical protein -
ER16_RS14880 1909395..1909499 - 105 WP_001670380.1 transposase -
ER16_RS15305 1909644..1909739 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1909767..1909824 - 58 - - Antitoxin
ER16_RS09375 1909862..1909963 + 102 WP_001791232.1 hypothetical protein -
ER16_RS15310 1909941..1910113 - 173 Protein_1802 transposase -
ER16_RS09380 1910307..1910684 - 378 WP_001036002.1 DUF1433 domain-containing protein -
ER16_RS09385 1910890..1911330 - 441 WP_000759947.1 DUF1433 domain-containing protein -
ER16_RS09390 1911375..1912988 + 1614 WP_000926708.1 lipase -
ER16_RS09395 1913003..1913302 + 300 WP_000095392.1 WXG100 family type VII secretion target -
ER16_RS09400 1913619..1914800 - 1182 WP_000162901.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk 1900664..1926054 25390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T46802 WP_001801861.1 NZ_CP007659:1909644-1909739 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T46802 NZ_CP007659:1909644-1909739 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT46802 NZ_CP007659:c1909824-1909767 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References