Detailed information of TA system TA046799

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1574756..1575335
• Replicon: chromosome
• Accession: NZ_CP007659
• Organism: Staphylococcus aureus strain H-EMRSA-15

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: ER16_RS07660
• Protein ID: WP_001025401.1
• Coordinates: 1575090..1575335 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1574756..1575121 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ER16_RS07620	1571502..1572056	-	555	WP_000647288.1	DUF2815 family protein	-
ER16_RS07625	1572082..1573248	-	1167	WP_000762534.1	DUF2800 domain-containing protein	-
ER16_RS07630	1573245..1573607	-	363	WP_000985986.1	hypothetical protein	-
ER16_RS07635	1573622..1573945	-	324	WP_000175000.1	hypothetical protein	-
ER16_RS07640	1574024..1574185	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
ER16_RS07645	1574198..1574461	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
ER16_RS07650	1574486..1574701	-	216	WP_001097552.1	hypothetical protein	-
ER16_RS07655	1574756..1575121	+	366	WP_001128433.1	hypothetical protein	Antitoxin
ER16_RS07660	1575090..1575335	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
ER16_RS07665	1575402..1575782	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
ER16_RS07670	1575769..1575966	-	198	WP_001148860.1	hypothetical protein	-
ER16_RS07675	1576036..1576248	+	213	WP_000362644.1	hypothetical protein	-
ER16_RS15430	1576289..1576438	-	150	WP_000771849.1	hypothetical protein	-
ER16_RS07680	1576453..1576896	-	444	WP_000435357.1	hypothetical protein	-
ER16_RS07685	1576944..1577156	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
ER16_RS07690	1577308..1578039	+	732	WP_000511090.1	XRE family transcriptional regulator	-
ER16_RS07695	1578110..1578292	+	183	WP_000705240.1	hypothetical protein	-
ER16_RS07700	1578329..1578475	+	147	WP_001795334.1	hypothetical protein	-
ER16_RS07705	1578472..1579086	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1534154..1600263	66109

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T46799 WP_001025401.1 NZ_CP007659:c1575335-1575090 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T46799 NZ_CP007659:c1575335-1575090 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT46799 NZ_CP007659:1574756-1575121 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin