Detailed information of TA system TA046796

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 1538912..1539219
• Replicon: chromosome
• Accession: NZ_CP007659
• Organism: Staphylococcus aureus strain H-EMRSA-15

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: ER16_RS14815
• Protein ID: WP_011447039.1
• Coordinates: 1539043..1539219 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1538912..1539051 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ER16_RS15425	1534154..1534369	-	216	WP_170267452.1	hypothetical protein	-
ER16_RS07380	1534548..1535558	-	1011	WP_000777019.1	restriction endonuclease subunit S	-
ER16_RS07385	1535545..1537449	-	1905	WP_001003363.1	N-6 DNA methylase	-
ER16_RS07395	1537810..1538565	-	756	WP_000861038.1	CHAP domain-containing protein	-
ER16_RS07400	1538577..1538831	-	255	WP_000611512.1	phage holin	-
ER16_RS07405	1538883..1538990	+	108	WP_001791821.1	hypothetical protein	-
-	1538912..1539051	+	140	NuclAT_0	-	Antitoxin
-	1538912..1539051	+	140	NuclAT_0	-	Antitoxin
-	1538912..1539051	+	140	NuclAT_0	-	Antitoxin
-	1538912..1539051	+	140	NuclAT_0	-	Antitoxin
ER16_RS14815	1539043..1539219	-	177	WP_011447039.1	putative holin-like toxin	Toxin
ER16_RS07415	1539372..1539671	-	300	WP_000466784.1	DUF2951 domain-containing protein	-
ER16_RS07420	1539717..1539881	-	165	WP_000916020.1	XkdX family protein	-
ER16_RS07425	1539874..1540263	-	390	WP_001166596.1	DUF2977 domain-containing protein	-
ER16_RS07430	1540263..1541729	-	1467	WP_000067127.1	BppU family phage baseplate upper protein	-
ER16_RS07435	1541729..1543639	-	1911	WP_000429558.1	minor structural protein	-
ER16_RS07440	1543655..1543945	-	291	WP_000179858.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1534154..1600263	66109

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T46796 WP_011447039.1 NZ_CP007659:c1539219-1539043 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T46796 NZ_CP007659:c1539219-1539043 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGGTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT46796 NZ_CP007659:1538912-1539051 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin