Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2514204..2514388 Replicon chromosome
Accession NZ_CP007657
Organism Staphylococcus aureus strain V2200

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag EP20_RS12915 Protein ID WP_000482650.1
Coordinates 2514281..2514388 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2514204..2514264 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP20_RS12890 2509734..2509901 - 168 WP_031929627.1 hypothetical protein -
EP20_RS12900 2510132..2511865 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
EP20_RS12905 2511890..2513653 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2514204..2514264 + 61 - - Antitoxin
EP20_RS12915 2514281..2514388 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
EP20_RS12920 2514522..2514908 - 387 WP_000779358.1 flippase GtxA -
EP20_RS12925 2515176..2516318 + 1143 WP_001176863.1 glycerate kinase -
EP20_RS12930 2516378..2517037 + 660 WP_000831298.1 membrane protein -
EP20_RS12935 2517219..2518430 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
EP20_RS12940 2518553..2519026 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T46792 WP_000482650.1 NZ_CP007657:c2514388-2514281 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T46792 NZ_CP007657:c2514388-2514281 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT46792 NZ_CP007657:2514204-2514264 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References