Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-SprF3/- |
| Location | 2049873..2050172 | Replicon | chromosome |
| Accession | NZ_CP007657 | ||
| Organism | Staphylococcus aureus strain V2200 | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | Q2FWU9 |
| Locus tag | EP20_RS15190 | Protein ID | WP_011447039.1 |
| Coordinates | 2049996..2050172 (-) | Length | 59 a.a. |
Antitoxin (RNA)
| Gene name | SprF3 | ||
| Locus tag | - | ||
| Coordinates | 2049873..2049928 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EP20_RS10295 | 2045204..2045464 | + | 261 | WP_001791826.1 | hypothetical protein | - |
| EP20_RS10300 | 2045517..2045867 | - | 351 | WP_000702263.1 | complement inhibitor SCIN-A | - |
| EP20_RS10305 | 2046552..2047001 | + | 450 | WP_000727649.1 | chemotaxis-inhibiting protein CHIPS | - |
| EP20_RS15535 | 2047096..2047431 | - | 336 | Protein_1946 | SH3 domain-containing protein | - |
| EP20_RS10315 | 2048081..2048572 | - | 492 | WP_000920037.1 | staphylokinase | - |
| EP20_RS10320 | 2048763..2049518 | - | 756 | WP_000861038.1 | CHAP domain-containing protein | - |
| EP20_RS10325 | 2049530..2049784 | - | 255 | WP_000611512.1 | phage holin | - |
| EP20_RS10330 | 2049836..2049943 | + | 108 | WP_001791821.1 | hypothetical protein | - |
| - | 2049865..2050004 | + | 140 | NuclAT_0 | - | - |
| - | 2049865..2050004 | + | 140 | NuclAT_0 | - | - |
| - | 2049865..2050004 | + | 140 | NuclAT_0 | - | - |
| - | 2049865..2050004 | + | 140 | NuclAT_0 | - | - |
| - | 2049873..2049928 | + | 56 | - | - | Antitoxin |
| EP20_RS15190 | 2049996..2050172 | - | 177 | WP_011447039.1 | putative holin-like toxin | Toxin |
| EP20_RS10335 | 2050322..2050618 | - | 297 | WP_000539688.1 | DUF2951 domain-containing protein | - |
| EP20_RS10340 | 2050676..2050963 | - | 288 | WP_001040261.1 | hypothetical protein | - |
| EP20_RS10345 | 2051010..2051162 | - | 153 | WP_001153681.1 | hypothetical protein | - |
| EP20_RS10350 | 2051152..2054937 | - | 3786 | WP_000582137.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / chp / sak / hlb / groEL | 2045517..2104270 | 58753 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T46783 WP_011447039.1 NZ_CP007657:c2050172-2049996 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T46783 NZ_CP007657:c2050172-2049996 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 56 bp
>AT46783 NZ_CP007657:2049873-2049928 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
