Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 14167..14702 Replicon plasmid pLMP1046
Accession NZ_CP007649
Organism Ligilactobacillus salivarius strain JCM1046

Toxin (Protein)


Gene name yoeB Uniprot ID A0A089QGD7
Locus tag LSJ_RS10915 Protein ID WP_044005934.1
Coordinates 14167..14439 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A089QLK8
Locus tag LSJ_RS10920 Protein ID WP_044005935.1
Coordinates 14439..14702 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSJ_RS10900 10599..11588 - 990 WP_044005931.1 hypothetical protein -
LSJ_RS10905 11805..13109 + 1305 WP_044005932.1 hypothetical protein -
LSJ_RS10910 13173..14096 + 924 WP_044005933.1 site-specific integrase -
LSJ_RS10915 14167..14439 - 273 WP_044005934.1 Txe/YoeB family addiction module toxin Toxin
LSJ_RS10920 14439..14702 - 264 WP_044005935.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LSJ_RS10925 14964..18383 - 3420 WP_044005936.1 SEC10/PgrA surface exclusion domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..101883 101883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-68)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10795.33 Da        Isoelectric Point: 10.3175

>T46779 WP_044005934.1 NZ_CP007649:c14439-14167 [Ligilactobacillus salivarius]
MAEEEYRVRIKNSAKSDLKKLKRSNLQDSFDAIIKQLKKNPFEHNQGYEKLRPPIDGKYSRRINVQHRVVYTVDKKDKIV
NIYSAWSHYE

Download         Length: 273 bp

>T46779 NZ_CP007649:c14439-14167 [Ligilactobacillus salivarius]
ATGGCAGAGGAAGAATATAGAGTTCGGATTAAAAATTCAGCCAAATCTGATCTAAAAAAACTTAAACGAAGTAACTTGCA
AGATTCATTTGATGCTATAATTAAACAATTAAAGAAGAATCCTTTTGAACATAATCAGGGATATGAGAAACTTAGACCAC
CAATTGACGGAAAGTATTCTAGAAGAATCAATGTTCAACATCGAGTTGTTTATACAGTTGACAAGAAAGATAAGATTGTA
AATATCTATTCAGCATGGTCACATTACGAATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9841.96 Da        Isoelectric Point: 4.4287

>AT46779 WP_044005935.1 NZ_CP007649:c14702-14439 [Ligilactobacillus salivarius]
MSNILTPTNARKNFYGLLKQVNNDHKPVIISSAKSSNADAVLISKADWDSIQETMYLERIGVGKVVREREQDDSGFTDID
DINWDEL

Download         Length: 264 bp

>AT46779 NZ_CP007649:c14702-14439 [Ligilactobacillus salivarius]
ATGAGTAATATACTTACACCAACAAATGCACGTAAAAATTTTTATGGATTACTTAAACAGGTTAACAATGACCACAAGCC
GGTTATTATTTCATCGGCAAAGTCATCTAATGCTGATGCTGTTTTAATCAGCAAAGCTGACTGGGACTCAATTCAAGAAA
CAATGTACCTTGAAAGGATTGGAGTAGGAAAAGTTGTTCGTGAACGAGAACAAGATGATAGTGGCTTTACTGATATTGAT
GATATAAATTGGGATGAGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A089QGD7

Antitoxin

Source ID Structure
AlphaFold DB A0A089QLK8

References