Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1871685..1872198 Replicon chromosome
Accession NZ_CP007632
Organism Streptococcus agalactiae strain NGBS572

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag EN73_RS09400 Protein ID WP_000481712.1
Coordinates 1871685..1871939 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag EN73_RS09405 Protein ID WP_000387490.1
Coordinates 1871932..1872198 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EN73_RS09380 1867456..1869957 - 2502 WP_000239404.1 ATP-binding protein -
EN73_RS09385 1869978..1870388 - 411 WP_000390749.1 conjugal transfer protein -
EN73_RS09390 1870392..1870658 - 267 WP_001055037.1 hypothetical protein -
EN73_RS09395 1870679..1871632 - 954 WP_000565541.1 conjugal transfer protein -
EN73_RS09400 1871685..1871939 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
EN73_RS09405 1871932..1872198 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EN73_RS09410 1872343..1872816 - 474 WP_000560386.1 hypothetical protein -
EN73_RS09415 1872824..1873306 - 483 WP_000383283.1 antirestriction protein ArdA -
EN73_RS09420 1873359..1873631 - 273 WP_000072643.1 hypothetical protein -
EN73_RS09425 1873763..1874116 - 354 WP_000571928.1 helix-turn-helix domain-containing protein -
EN73_RS09430 1874109..1874339 - 231 WP_001866982.1 helix-turn-helix domain-containing protein -
EN73_RS09435 1874326..1874703 - 378 WP_000287185.1 hypothetical protein -
EN73_RS09440 1874719..1875951 - 1233 WP_000338839.1 replication initiation factor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cfa/cfb 1856518..1896115 39597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T46745 WP_000481712.1 NZ_CP007632:c1871939-1871685 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T46745 NZ_CP007632:c1871939-1871685 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT46745 WP_000387490.1 NZ_CP007632:c1872198-1871932 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT46745 NZ_CP007632:c1872198-1871932 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References