Detailed information of TA system TA046726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 23286..23809
• Replicon: plasmid pAYP1020
• Accession: NZ_CP007602
• Organism: Staphylococcus capitis subsp. capitis strain AYP1020

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: ayp1020_RS11730
• Protein ID: WP_047797134.1
• Coordinates: 23543..23809 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: ayp1020_RS11725
• Protein ID: WP_047797133.1
• Coordinates: 23286..23543 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ayp1020_RS11695	19691..20032	+	342	WP_047797127.1	hypothetical protein	-
ayp1020_RS11700	20125..20379	+	255	WP_047797128.1	hypothetical protein	-
ayp1020_RS11705	20392..20928	+	537	WP_047797129.1	hypothetical protein	-
ayp1020_RS11710	20943..21728	+	786	WP_047797130.1	hypothetical protein	-
ayp1020_RS11715	21748..22407	+	660	WP_047797131.1	CPBP family intramembrane metalloprotease	-
ayp1020_RS11720	22680..23075	+	396	WP_053035569.1	YolD-like family protein	-
ayp1020_RS11725	23286..23543	+	258	WP_047797133.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ayp1020_RS11730	23543..23809	+	267	WP_047797134.1	Txe/YoeB family addiction module toxin	Toxin
ayp1020_RS11735	23833..24027	+	195	WP_047797135.1	hypothetical protein	-
ayp1020_RS11740	24321..24713	+	393	WP_047797136.1	hypothetical protein	-
ayp1020_RS11745	24953..25726	+	774	WP_047797137.1	hypothetical protein	-
ayp1020_RS11755	26226..26798	+	573	WP_047797139.1	recombinase family protein	-
ayp1020_RS11760	26837..27547	+	711	WP_047797140.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59661	59661

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10549.04 Da
• Isoelectric Point: 10.0031

>T46726 WP_047797134.1 NZ_CP007602:23543-23809 [Staphylococcus capitis subsp. capitis]
MTNYTVNIHNSAKSDLKKLKRSHLKETLLNIIDTLKNDPYEHSQSFEKIQPKHLGRYLRRLNHQHRVVYRIDEDNKEVLI
LSAWSHCQ

Nucleotide

• Length: 267 bp

>T46726 NZ_CP007602:23543-23809 [Staphylococcus capitis subsp. capitis]
ATGACTAATTATACGGTTAACATTCATAATTCGGCAAAGTCAGATTTAAAGAAACTGAAACGTTCTCATTTAAAAGAAAC
ATTACTAAATATAATAGATACACTTAAAAATGATCCATACGAACATAGCCAATCCTTTGAAAAAATACAACCTAAACACT
TGGGCAGATATTTAAGACGGCTTAATCATCAACACAGAGTGGTTTATAGGATTGATGAAGATAATAAAGAAGTATTGATA
CTTTCAGCTTGGTCACATTGTCAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9938.08 Da
• Isoelectric Point: 4.4734

>AT46726 WP_047797133.1 NZ_CP007602:23286-23543 [Staphylococcus capitis subsp. capitis]
MIIKNPTDARKEFYQLLKNVNDKHEPVFINGKNKDNDAVIIAMSDWKSMQETIYLEATGTMDQVREREKYNNGSTNVDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT46726 NZ_CP007602:23286-23543 [Staphylococcus capitis subsp. capitis]
ATGATAATTAAAAATCCAACTGATGCTAGGAAAGAATTTTATCAATTATTAAAAAATGTTAATGATAAGCATGAACCTGT
TTTTATTAATGGAAAGAATAAAGATAATGATGCTGTTATTATTGCAATGAGTGATTGGAAAAGTATGCAAGAAACAATAT
ATTTAGAAGCAACAGGAACGATGGATCAAGTGAGAGAACGAGAAAAGTATAATAATGGATCAACCAATGTAGATGATATT
GATTGGGATAATCTTTAA