Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3558814..3559507 Replicon chromosome
Accession NZ_CP007594
Organism Escherichia coli strain SEC470

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag DP32_RS17915 Protein ID WP_000415584.1
Coordinates 3559211..3559507 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag DP32_RS17910 Protein ID WP_000650107.1
Coordinates 3558814..3559209 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DP32_RS17900 3554678..3556936 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
DP32_RS17905 3557074..3558681 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
DP32_RS17910 3558814..3559209 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
DP32_RS17915 3559211..3559507 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
DP32_RS17920 3559712..3560194 - 483 WP_000183505.1 transcriptional regulator -
DP32_RS17925 3560247..3560639 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
DP32_RS17930 3560791..3561450 + 660 WP_001221493.1 two-component system response regulator QseB -
DP32_RS17935 3561447..3562796 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
DP32_RS17940 3562842..3563126 - 285 WP_042199439.1 DUF2645 family protein -
DP32_RS17945 3563159..3563856 - 698 Protein_3409 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3563159..3563662 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T46706 WP_000415584.1 NZ_CP007594:c3559507-3559211 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T46706 NZ_CP007594:c3559507-3559211 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT46706 WP_000650107.1 NZ_CP007594:c3559209-3558814 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT46706 NZ_CP007594:c3559209-3558814 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References