Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3027519..3028188 Replicon chromosome
Accession NZ_CP007542
Organism Synechocystis sp. PCC 6714

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D082_RS17825 Protein ID WP_071880822.1
Coordinates 3027519..3027851 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D082_RS13780 Protein ID WP_028947089.1
Coordinates 3027874..3028188 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D082_RS13760 3022694..3024040 - 1347 WP_028947094.1 hemolysin family protein -
D082_RS13765 3024330..3024578 + 249 WP_028947093.1 30S ribosomal protein S16 -
D082_RS13770 3024620..3024979 + 360 WP_028947092.1 KH domain-containing protein -
D082_RS13775 3025173..3027347 + 2175 WP_028947091.1 glutamine synthetase III -
D082_RS17825 3027519..3027851 + 333 WP_071880822.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D082_RS13780 3027874..3028188 + 315 WP_028947089.1 HigA family addiction module antidote protein Antitoxin
D082_RS13785 3028488..3028970 - 483 WP_028947088.1 cytochrome c-550 -
D082_RS13790 3029128..3029328 - 201 WP_028947087.1 hypothetical protein -
D082_RS13795 3029667..3030416 + 750 WP_028947086.1 sirohydrochlorin chelatase -
D082_RS13800 3030409..3030882 - 474 WP_028947085.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
D082_RS13805 3030947..3031927 - 981 WP_028947084.1 acetyl-CoA carboxylase carboxyl transferase subunit alpha -
D082_RS13810 3032404..3032661 + 258 WP_028947083.1 DUF4327 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(21-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-67)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12657.37 Da        Isoelectric Point: 9.7786

>T46599 WP_071880822.1 NZ_CP007542:3027519-3027851 [Synechocystis sp. PCC 6714]
MGDCRSLPSLTYYAKRNTIQSFRCKHTQSLFEGGDPSRFRAFKDTAIRKLTQLEAAQTLEFLRSPPGNQLEALKGNRKGQ
YSIRISSQFRLCFIWTNNGPTDVEIVDYYP

Download         Length: 333 bp

>T46599 NZ_CP007542:3027519-3027851 [Synechocystis sp. PCC 6714]
ATGGGCGATTGCCGCTCATTACCTTCGTTGACGTATTACGCAAAACGGAATACGATTCAATCTTTCCGATGTAAGCATAC
GCAATCACTTTTTGAAGGAGGCGATCCATCCCGTTTTCGTGCTTTCAAAGATACTGCGATTCGGAAGTTGACTCAATTGG
AGGCAGCCCAAACCTTAGAATTCTTACGTTCTCCACCAGGCAATCAACTTGAAGCGTTAAAAGGTAATAGAAAAGGACAA
TACAGTATTCGGATTAGTTCCCAATTTCGATTGTGTTTTATCTGGACAAATAATGGTCCTACTGATGTTGAAATTGTTGA
TTATTACCCGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11965.84 Da        Isoelectric Point: 7.3198

>AT46599 WP_028947089.1 NZ_CP007542:3027874-3028188 [Synechocystis sp. PCC 6714]
MINRPINRMRPVHPGEILREDFLEPLDMSINALALALNVPPSRIHEIIKERRAITADTAERLARYFGGDGASWLNLQAIY
DLKTLPNRDEIMQRIQPRISEHIA

Download         Length: 315 bp

>AT46599 NZ_CP007542:3027874-3028188 [Synechocystis sp. PCC 6714]
ATGATAAACCGCCCAATTAATCGAATGCGCCCCGTTCATCCCGGCGAGATTTTGCGGGAAGATTTTCTTGAGCCTCTGGA
TATGAGCATCAATGCTTTAGCTTTAGCCTTAAATGTTCCTCCCTCTCGTATTCACGAAATTATTAAAGAACGCCGTGCTA
TTACGGCTGATACTGCAGAAAGATTAGCGCGCTATTTTGGCGGCGATGGTGCTTCTTGGCTAAACTTACAAGCAATTTAT
GATTTAAAAACTTTACCTAATCGTGATGAAATCATGCAACGAATTCAGCCCCGCATCTCAGAACACATTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References