Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2670815..2671338 Replicon chromosome
Accession NZ_CP007539
Organism Staphylococcus aureus strain FDAARGOS_5

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag X998_RS13880 Protein ID WP_000074048.1
Coordinates 2671072..2671338 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag X998_RS13875 Protein ID WP_000587616.1
Coordinates 2670815..2671072 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
X998_RS13850 2665895..2667088 + 1194 WP_000675395.1 MFS transporter -
X998_RS13855 2667312..2668061 - 750 WP_000072443.1 hypothetical protein -
X998_RS13860 2668256..2669833 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
X998_RS13865 2670001..2670456 - 456 WP_000732082.1 DUF1307 domain-containing protein -
X998_RS13870 2670515..2670709 + 195 WP_001790145.1 hypothetical protein -
X998_RS13875 2670815..2671072 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
X998_RS13880 2671072..2671338 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
X998_RS13885 2671693..2672769 + 1077 WP_001076671.1 M42 family metallopeptidase -
X998_RS13890 2673017..2673679 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
X998_RS13895 2673672..2674448 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
X998_RS13900 2674844..2676031 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T46594 WP_000074048.1 NZ_CP007539:2671072-2671338 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T46594 NZ_CP007539:2671072-2671338 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT46594 WP_000587616.1 NZ_CP007539:2670815-2671072 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT46594 NZ_CP007539:2670815-2671072 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References