Detailed information of TA system TA046580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3814354..3815012
• Replicon: chromosome
• Accession: NZ_CP007535
• Organism: Acinetobacter baumannii strain AC29

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BL01_RS18315
• Protein ID: WP_000312250.1
• Coordinates: 3814653..3815012 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BL01_RS18310
• Protein ID: WP_001096429.1
• Coordinates: 3814354..3814653 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BL01_RS18300	3809661..3812210	-	2550	Protein_3580	adhesin	-
BL01_RS18305	3812415..3814232	+	1818	Protein_3581	adhesin	-
BL01_RS18310	3814354..3814653	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
BL01_RS18315	3814653..3815012	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BL01_RS18320	3815213..3815779	+	567	WP_000710385.1	hypothetical protein	-
BL01_RS18325	3815828..3816010	+	183	WP_000373385.1	hypothetical protein	-
BL01_RS18330	3816077..3816775	+	699	WP_000873188.1	hypothetical protein	-
BL01_RS18335	3816914..3817297	+	384	WP_000654348.1	hypothetical protein	-
BL01_RS18340	3817364..3818122	+	759	WP_001053128.1	hypothetical protein	-
BL01_RS18345	3818174..3818509	+	336	WP_000653925.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T46580 WP_000312250.1 NZ_CP007535:c3815012-3814653 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T46580 NZ_CP007535:c3815012-3814653 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGTCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTATGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT46580 WP_001096429.1 NZ_CP007535:c3814653-3814354 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT46580 NZ_CP007535:c3814653-3814354 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA