Detailed information of TA system TA046547

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2170878..2171185
• Replicon: chromosome
• Accession: NZ_CP007499
• Organism: Staphylococcus aureus strain 2395 USA500

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CH51_RS16110
• Protein ID: WP_011447039.1
• Coordinates: 2171009..2171185 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2170878..2171017 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH51_RS11075	2166444..2166623	+	180	WP_000669791.1	hypothetical protein	-
CH51_RS11085	2166934..2167194	+	261	WP_001791826.1	hypothetical protein	-
CH51_RS11090	2167247..2167597	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CH51_RS11095	2168108..2168443	-	336	Protein_2105	SH3 domain-containing protein	-
CH51_RS11100	2169094..2169585	-	492	WP_000920038.1	staphylokinase	-
CH51_RS11105	2169776..2170531	-	756	WP_000861038.1	CHAP domain-containing protein	-
CH51_RS11110	2170543..2170797	-	255	WP_000611508.1	phage holin	-
CH51_RS11115	2170849..2170956	+	108	WP_031762631.1	hypothetical protein	-
-	2170878..2171017	+	140	NuclAT_0	-	Antitoxin
-	2170878..2171017	+	140	NuclAT_0	-	Antitoxin
-	2170878..2171017	+	140	NuclAT_0	-	Antitoxin
-	2170878..2171017	+	140	NuclAT_0	-	Antitoxin
CH51_RS16110	2171009..2171185	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CH51_RS11125	2171294..2172067	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
CH51_RS11130	2172440..2172814	-	375	WP_000340977.1	hypothetical protein	-
CH51_RS11135	2172870..2173157	-	288	WP_001262621.1	hypothetical protein	-
CH51_RS11140	2173203..2173355	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / sak / sea / hlb / groEL	2116637..2225008	108371

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T46547 WP_011447039.1 NZ_CP007499:c2171185-2171009 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T46547 NZ_CP007499:c2171185-2171009 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT46547 NZ_CP007499:2170878-2171017 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCGATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin