Detailed information of TA system TA046544

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2010552..2010734
• Replicon: chromosome
• Accession: NZ_CP007499
• Organism: Staphylococcus aureus strain 2395 USA500

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: CH51_RS16455
• Protein ID: WP_001801861.1
• Coordinates: 2010552..2010647 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2010675..2010734 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH51_RS10090	2006212..2006838	+	627	WP_000669046.1	hypothetical protein	-
CH51_RS10095	2006879..2007223	+	345	WP_000627551.1	DUF3969 family protein	-
CH51_RS10100	2007321..2007872	+	552	WP_000414205.1	hypothetical protein	-
CH51_RS10105	2008090..2008731	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
CH51_RS10110	2008845..2009030	-	186	WP_000809857.1	hypothetical protein	-
CH51_RS10115	2009032..2009208	-	177	WP_000375476.1	hypothetical protein	-
CH51_RS10120	2009219..2009602	-	384	WP_000070811.1	hypothetical protein	-
CH51_RS10130	2010206..2010349	-	144	WP_001549059.1	transposase	-
CH51_RS16455	2010552..2010647	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2010675..2010734	-	60	-	-	Antitoxin
CH51_RS10135	2010770..2010871	+	102	WP_001791893.1	hypothetical protein	-
CH51_RS16030	2010849..2011025	-	177	Protein_1954	transposase	-
CH51_RS10140	2011219..2011596	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1973113..2091488	118375

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-98)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T46544 WP_001801861.1 NZ_CP007499:2010552-2010647 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T46544 NZ_CP007499:2010552-2010647 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT46544 NZ_CP007499:c2010734-2010675 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin