Detailed information of TA system TA046503

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA-HipA
• Location: 1047776..1049124
• Replicon: chromosome
• Accession: NZ_CP007472
• Organism: Haemophilus influenzae strain 723

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: NTHI723_RS05145
• Protein ID: WP_044364635.1
• Coordinates: 1048093..1049124 (+)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A806DF96
• Locus tag: NTHI723_RS05140
• Protein ID: WP_020910207.1
• Coordinates: 1047776..1048096 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NTHI723_RS05100	1043189..1043467	+	279	WP_005661211.1	cell division protein FtsB	-
NTHI723_RS05105	1043467..1044144	+	678	WP_011272161.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
NTHI723_RS05110	1044141..1044617	+	477	WP_006995249.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
NTHI723_RS05115	1044924..1045358	-	435	WP_005650818.1	D-tyrosyl-tRNA(Tyr) deacylase	-
NTHI723_RS05120	1045355..1045795	-	441	WP_005667635.1	FMN-binding protein MioC	-
NTHI723_RS05125	1045894..1046112	-	219	WP_005650820.1	cell division protein ZapB	-
NTHI723_RS05130	1046274..1047275	+	1002	WP_011272160.1	class II fructose-bisphosphatase	-
NTHI723_RS05135	1047480..1047788	+	309	WP_044364634.1	helix-turn-helix domain-containing protein	-
NTHI723_RS05140	1047776..1048096	+	321	WP_020910207.1	type II toxin-antitoxin system HipA family toxin	Antitoxin
NTHI723_RS05145	1048093..1049124	+	1032	WP_044364635.1	type II toxin-antitoxin system HipA family toxin	Toxin
NTHI723_RS05150	1049207..1050865	-	1659	WP_044364637.1	thiol reductant ABC exporter subunit CydC	-
NTHI723_RS05155	1050858..1052603	-	1746	WP_044364639.1	ABC transporter ATP-binding protein/permease	-
NTHI723_RS05160	1052652..1052816	-	165	WP_044364641.1	hypothetical protein	-
NTHI723_RS09640	1052869..1053033	-	165	WP_044364643.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39847.43 Da
• Isoelectric Point: 6.4335

>T46503 WP_044364635.1 NZ_CP007472:1048093-1049124 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDDHFNSINQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDKQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLVREEGNDTLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Nucleotide

• Length: 1032 bp

>T46503 NZ_CP007472:1048093-1049124 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCTTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCGAAGATGATCACTTTAACAGCATAAATCAACAG
GGAAACTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAAGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATAAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGTGCGAGAAGAGGGTAATGACACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCGTTACTTAACGTATTAAATGAACCTGAACTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12438.06 Da
• Isoelectric Point: 5.8850

>AT46503 WP_020910207.1 NZ_CP007472:1047776-1048096 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT46503 NZ_CP007472:1047776-1048096 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCATGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: A0A806DF96