Detailed information of TA system TA046495

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA-HipA
• Location: 329139..330487
• Replicon: chromosome
• Accession: NZ_CP007471
• Organism: Haemophilus influenzae strain C486

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: NTHIC486_RS01650
• Protein ID: WP_044345221.1
• Coordinates: 329456..330487 (+)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A2R3FM14
• Locus tag: NTHIC486_RS01645
• Protein ID: WP_005687922.1
• Coordinates: 329139..329459 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NTHIC486_RS01605	324567..324845	+	279	WP_005665661.1	cell division protein FtsB	-
NTHIC486_RS01610	324845..325522	+	678	WP_005655267.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
NTHIC486_RS01615	325519..325995	+	477	WP_005687916.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
NTHIC486_RS01620	326297..326731	-	435	WP_005687917.1	D-tyrosyl-tRNA(Tyr) deacylase	-
NTHIC486_RS01625	326728..327168	-	441	WP_005687918.1	FMN-binding protein MioC	-
NTHIC486_RS01630	327262..327480	-	219	WP_005650820.1	cell division protein ZapB	-
NTHIC486_RS01635	327642..328643	+	1002	WP_005687920.1	class II fructose-bisphosphatase	-
NTHIC486_RS01640	328843..329151	+	309	WP_005661200.1	helix-turn-helix domain-containing protein	-
NTHIC486_RS01645	329139..329459	+	321	WP_005687922.1	type II toxin-antitoxin system HipA family toxin	Antitoxin
NTHIC486_RS01650	329456..330487	+	1032	WP_044345221.1	type II toxin-antitoxin system HipA family toxin	Toxin
NTHIC486_RS01655	330571..332229	-	1659	WP_044345222.1	thiol reductant ABC exporter subunit CydC	-
NTHIC486_RS01660	332222..333967	-	1746	WP_044345224.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39860.37 Da
• Isoelectric Point: 6.5052

>T46495 WP_044345221.1 NZ_CP007471:329456-330487 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSDYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDGHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLTLLNVLNEPEL

Nucleotide

• Length: 1032 bp

>T46495 NZ_CP007471:329456-330487 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGACTACAGCACAAAAGGTTTACATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGGGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAACAAACAGAGATTCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAACGTTACTTAACGTATTAAATGAACCTGAGCTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12407.09 Da
• Isoelectric Point: 5.9670

>AT46495 WP_005687922.1 NZ_CP007471:329139-329459 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT46495 NZ_CP007471:329139-329459 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAGGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: A0A2R3FM14