Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 1716272..1716550 Replicon chromosome
Accession NZ_CP007454
Organism Staphylococcus aureus strain 502A isolate RN6607

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag CH52_RS08595 Protein ID WP_001802298.1
Coordinates 1716272..1716376 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 1716372..1716550 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH52_RS08585 1713069..1713851 + 783 WP_000908182.1 ABC transporter ATP-binding protein -
CH52_RS08590 1713919..1714776 + 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
CH52_RS14610 1715434..1715592 - 159 WP_001792784.1 hypothetical protein -
CH52_RS08595 1716272..1716376 + 105 WP_001802298.1 hypothetical protein Toxin
- 1716372..1716550 - 179 - - Antitoxin
CH52_RS08600 1716809..1717900 - 1092 WP_000495669.1 hypothetical protein -
CH52_RS08605 1718166..1719143 - 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
CH52_RS08610 1719145..1719465 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
CH52_RS08615 1719617..1720282 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T46472 WP_001802298.1 NZ_CP007454:1716272-1716376 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T46472 NZ_CP007454:1716272-1716376 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 179 bp

>AT46472 NZ_CP007454:c1716550-1716372 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References