Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1456399..1456916 Replicon chromosome
Accession NZ_CP007454
Organism Staphylococcus aureus strain 502A isolate RN6607

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag CH52_RS07240 Protein ID WP_000113265.1
Coordinates 1456650..1456916 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CH52_RS07235 Protein ID WP_000584499.1
Coordinates 1456399..1456650 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH52_RS07205 1452097..1452816 + 720 WP_000479576.1 amino acid ABC transporter permease -
CH52_RS07210 1452813..1453544 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
CH52_RS07215 1453641..1454891 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
CH52_RS07220 1455146..1455508 + 363 WP_000819843.1 DUF4467 domain-containing protein -
CH52_RS07225 1455527..1456126 + 600 WP_000162810.1 DsbA family protein -
CH52_RS07230 1456133..1456234 + 102 Protein_1385 hypothetical protein -
CH52_RS07235 1456399..1456650 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CH52_RS07240 1456650..1456916 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
CH52_RS14555 1456951..1457022 + 72 Protein_1388 hypothetical protein -
CH52_RS07245 1457211..1458758 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CH52_RS07250 1458944..1459411 + 468 WP_000153347.1 SRPBCC domain-containing protein -
CH52_RS07255 1459495..1459677 + 183 WP_000230292.1 hypothetical protein -
CH52_RS07260 1459894..1460718 + 825 WP_000572035.1 formate/nitrite transporter family protein -
CH52_RS07265 1460952..1461488 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T46470 WP_000113265.1 NZ_CP007454:1456650-1456916 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T46470 NZ_CP007454:1456650-1456916 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT46470 WP_000584499.1 NZ_CP007454:1456399-1456650 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT46470 NZ_CP007454:1456399-1456650 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References