Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1431238..1431422 Replicon chromosome
Accession NZ_CP007454
Organism Staphylococcus aureus strain 502A isolate RN6607

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag CH52_RS07085 Protein ID WP_000482652.1
Coordinates 1431238..1431345 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1431362..1431422 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH52_RS07060 1426600..1427073 + 474 WP_000456486.1 GyrI-like domain-containing protein -
CH52_RS07065 1427196..1428407 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
CH52_RS07070 1428589..1429248 - 660 WP_000831298.1 membrane protein -
CH52_RS07075 1429308..1430450 - 1143 WP_001176863.1 glycerate kinase -
CH52_RS07080 1430718..1431104 + 387 WP_000779360.1 flippase GtxA -
CH52_RS07085 1431238..1431345 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1431362..1431422 - 61 - - Antitoxin
CH52_RS07095 1432048..1433811 + 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
CH52_RS07100 1433836..1435569 + 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
CH52_RS07110 1435800..1435967 + 168 Protein_1363 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T46468 WP_000482652.1 NZ_CP007454:1431238-1431345 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T46468 NZ_CP007454:1431238-1431345 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT46468 NZ_CP007454:c1431422-1431362 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References