46422

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 15382..15640 Replicon chromosome
Accession NZ_CP007442
Organism Escherichia coli ACN001

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag J444_RS00080 Protein ID WP_000809168.1
Coordinates 15382..15534 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15583..15640 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J444_RS00060 10623..11336 - 714 WP_001102383.1 acidic protein MsyB -
J444_RS00065 11362..11766 - 405 WP_000843559.1 DUF2541 family protein -
J444_RS00070 12143..14059 + 1917 WP_000516131.1 molecular chaperone DnaK -
J444_RS00075 14148..15278 + 1131 WP_001118464.1 molecular chaperone DnaJ -
J444_RS00080 15382..15534 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 15583..15640 + 58 - - Antitoxin
J444_RS00085 16120..17286 + 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
J444_RS00090 17352..18251 + 900 WP_001300855.1 transcriptional activator NhaR -
J444_RS26810 18290..19248 - 959 Protein_17 fimbrial family protein -
J444_RS00105 19261..20592 - 1332 Protein_18 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T46422 WP_000809168.1 NZ_CP007442:c15534-15382 [Escherichia coli ACN001]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T46422 NZ_CP007442:c15534-15382 [Escherichia coli ACN001]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT46422 NZ_CP007442:15583-15640 [Escherichia coli ACN001]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References