Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2884831..2885333 Replicon chromosome
Accession NZ_CP007393
Organism Escherichia coli strain ST2747

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag CF59_RS13995 Protein ID WP_000767829.1
Coordinates 2884831..2885085 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CF59_RS14000 Protein ID WP_025210604.1
Coordinates 2885082..2885333 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CF59_RS13980 2881324..2882682 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
CF59_RS26450 2882672..2882734 - 63 WP_010723108.1 membrane protein YoeI -
CF59_RS13985 2882949..2883878 - 930 WP_000803351.1 LysR family transcriptional regulator -
CF59_RS13990 2883924..2884748 - 825 WP_000754737.1 SDR family oxidoreductase -
CF59_RS13995 2884831..2885085 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
CF59_RS14000 2885082..2885333 - 252 WP_025210604.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
CF59_RS25420 2885616..2885666 + 51 WP_001364200.1 his operon leader peptide -
CF59_RS14005 2885812..2886711 + 900 WP_000131789.1 ATP phosphoribosyltransferase -
CF59_RS14010 2886717..2888021 + 1305 WP_025210605.1 histidinol dehydrogenase -
CF59_RS14015 2888018..2889088 + 1071 WP_001590288.1 histidinol-phosphate transaminase -
CF59_RS14020 2889088..2890155 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T46372 WP_000767829.1 NZ_CP007393:c2885085-2884831 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T46372 NZ_CP007393:c2885085-2884831 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9249.55 Da        Isoelectric Point: 5.0930

>AT46372 WP_025210604.1 NZ_CP007393:c2885333-2885082 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIGSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT46372 NZ_CP007393:c2885333-2885082 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAGGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGGTAGCCTGAAATCTGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References