Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2892591..2893093 Replicon chromosome
Accession NZ_CP007392
Organism Escherichia coli strain ST2747

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag CF58_RS14070 Protein ID WP_000767829.1
Coordinates 2892591..2892845 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CF58_RS14075 Protein ID WP_025210604.1
Coordinates 2892842..2893093 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CF58_RS14055 2889084..2890442 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
CF58_RS27175 2890432..2890494 - 63 WP_010723108.1 membrane protein YoeI -
CF58_RS14060 2890709..2891638 - 930 WP_000803351.1 LysR family transcriptional regulator -
CF58_RS14065 2891684..2892508 - 825 WP_000754737.1 SDR family oxidoreductase -
CF58_RS14070 2892591..2892845 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
CF58_RS14075 2892842..2893093 - 252 WP_025210604.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
CF58_RS25765 2893376..2893426 + 51 WP_001364200.1 his operon leader peptide -
CF58_RS14080 2893572..2894471 + 900 WP_000131789.1 ATP phosphoribosyltransferase -
CF58_RS14085 2894477..2895781 + 1305 WP_025210605.1 histidinol dehydrogenase -
CF58_RS14090 2895778..2896848 + 1071 WP_001590288.1 histidinol-phosphate transaminase -
CF58_RS14095 2896848..2897915 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T46342 WP_000767829.1 NZ_CP007392:c2892845-2892591 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T46342 NZ_CP007392:c2892845-2892591 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9249.55 Da        Isoelectric Point: 5.0930

>AT46342 WP_025210604.1 NZ_CP007392:c2893093-2892842 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIGSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT46342 NZ_CP007392:c2893093-2892842 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAGGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGGTAGCCTGAAATCTGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References