Detailed information of TA system TA046323

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 1946772..1946993
• Replicon: chromosome
• Accession: NZ_CP007392
• Organism: Escherichia coli strain ST2747

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A229AEQ8
• Locus tag: CF58_RS09350
• Protein ID: WP_000176713.1
• Coordinates: 1946772..1946879 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	1946927..1946993 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CF58_RS09325	1942617..1943699	+	1083	WP_025210407.1	peptide chain release factor 1	-
CF58_RS09330	1943699..1944532	+	834	WP_001578206.1	peptide chain release factor N(5)-glutamine methyltransferase	-
CF58_RS09335	1944529..1944921	+	393	WP_000200377.1	invasion regulator SirB2	-
CF58_RS09340	1944925..1945734	+	810	WP_025210408.1	invasion regulator SirB1	-
CF58_RS09345	1945770..1946624	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
CF58_RS09350	1946772..1946879	-	108	WP_000176713.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	1946927..1946993	+	67	NuclAT_13	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_13	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_13	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_13	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_15	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_15	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_15	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_15	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_17	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_17	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_17	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_17	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_19	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_19	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_19	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_19	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_21	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_21	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_21	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_21	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_23	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_23	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_23	-	Antitoxin
-	1946927..1946993	+	67	NuclAT_23	-	Antitoxin
-	1946929..1946992	+	64	NuclAT_38	-	-
-	1946929..1946992	+	64	NuclAT_38	-	-
-	1946929..1946992	+	64	NuclAT_38	-	-
-	1946929..1946992	+	64	NuclAT_38	-	-
-	1946929..1946992	+	64	NuclAT_40	-	-
-	1946929..1946992	+	64	NuclAT_40	-	-
-	1946929..1946992	+	64	NuclAT_40	-	-
-	1946929..1946992	+	64	NuclAT_40	-	-
CF58_RS09355	1947307..1947414	-	108	WP_000170955.1	small toxic polypeptide LdrA/LdrC	-
-	1947467..1947528	+	62	NuclAT_37	-	-
-	1947467..1947528	+	62	NuclAT_37	-	-
-	1947467..1947528	+	62	NuclAT_37	-	-
-	1947467..1947528	+	62	NuclAT_37	-	-
-	1947467..1947528	+	62	NuclAT_39	-	-
-	1947467..1947528	+	62	NuclAT_39	-	-
-	1947467..1947528	+	62	NuclAT_39	-	-
-	1947467..1947528	+	62	NuclAT_39	-	-
-	1947467..1947529	+	63	NuclAT_14	-	-
-	1947467..1947529	+	63	NuclAT_14	-	-
-	1947467..1947529	+	63	NuclAT_14	-	-
-	1947467..1947529	+	63	NuclAT_14	-	-
-	1947467..1947529	+	63	NuclAT_16	-	-
-	1947467..1947529	+	63	NuclAT_16	-	-
-	1947467..1947529	+	63	NuclAT_16	-	-
-	1947467..1947529	+	63	NuclAT_16	-	-
-	1947467..1947529	+	63	NuclAT_18	-	-
-	1947467..1947529	+	63	NuclAT_18	-	-
-	1947467..1947529	+	63	NuclAT_18	-	-
-	1947467..1947529	+	63	NuclAT_18	-	-
-	1947467..1947529	+	63	NuclAT_20	-	-
-	1947467..1947529	+	63	NuclAT_20	-	-
-	1947467..1947529	+	63	NuclAT_20	-	-
-	1947467..1947529	+	63	NuclAT_20	-	-
-	1947467..1947529	+	63	NuclAT_22	-	-
-	1947467..1947529	+	63	NuclAT_22	-	-
-	1947467..1947529	+	63	NuclAT_22	-	-
-	1947467..1947529	+	63	NuclAT_22	-	-
-	1947467..1947529	+	63	NuclAT_24	-	-
-	1947467..1947529	+	63	NuclAT_24	-	-
-	1947467..1947529	+	63	NuclAT_24	-	-
-	1947467..1947529	+	63	NuclAT_24	-	-
CF58_RS09360	1947820..1948920	-	1101	WP_001366250.1	sodium-potassium/proton antiporter ChaA	-
CF58_RS09365	1949190..1949420	+	231	WP_001578208.1	putative cation transport regulator ChaB	-
CF58_RS09370	1949578..1950273	+	696	WP_001295621.1	glutathione-specific gamma-glutamylcyclotransferase	-
CF58_RS09375	1950317..1950670	-	354	WP_001578209.1	DsrE/F sulfur relay family protein YchN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4031.79 Da
• Isoelectric Point: 11.4779

>T46323 WP_000176713.1 NZ_CP007392:c1946879-1946772 [Escherichia coli]
MTLTQFAMTFWHDLAAPILAGIITAAIVSWWRNRK

Nucleotide

• Length: 108 bp

>T46323 NZ_CP007392:c1946879-1946772 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT46323 NZ_CP007392:1946927-1946993 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A229AEQ8

Antitoxin