Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 4114563..4114832 Replicon chromosome
Accession NZ_CP007391
Organism Escherichia coli strain ST540

Toxin (Protein)


Gene name hok Uniprot ID P11895
Locus tag CF61_RS20625 Protein ID WP_001312861.1
Coordinates 4114674..4114832 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 4114563..4114628 (+)

Genomic Context


CF61_RS28465CF61_RS20595CF61_RS20600CF61_RS20605CF61_RS20610CF61_RS20615------CF61_RS20625CF61_RS28470CF61_RS20640CF61_RS20645CF61_RS20655CF61_RS20660CF61_RS20665CF61_RS28265CF61_RS20650
Location: 4110098..4110304 (207 bp)
Type: Others
Protein ID: WP_000275853.1
Location: 4110330..4110869 (540 bp)
Type: Others
Protein ID: WP_000290839.1
Location: 4110932..4111165 (234 bp)
Type: Others
Protein ID: WP_000005990.1
Location: 4111231..4113189 (1959 bp)
Type: Others
Protein ID: WP_025269850.1
Location: 4113244..4113678 (435 bp)
Type: Others
Protein ID: WP_001470779.1
Location: 4113675..4114394 (720 bp)
Type: Others
Protein ID: WP_001276232.1
Location: 4114406..4114630 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 4114406..4114630 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 4114406..4114630 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 4114406..4114630 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 4114563..4114628 (66 bp)
Type: Antitoxin
Protein ID: -
Location: 4114674..4114832 (159 bp)
Type: Toxin
Protein ID: WP_001312861.1
Location: 4115523..4115729 (207 bp)
Type: Others
Protein ID: WP_000547974.1
Location: 4115754..4116041 (288 bp)
Type: Others
Protein ID: WP_000107535.1
Location: 4116160..4116981 (822 bp)
Type: Others
Protein ID: WP_025269852.1
Location: 4118202..4118585 (384 bp)
Type: Others
Protein ID: WP_025269854.1
Location: 4118776..4119462 (687 bp)
Type: Others
Protein ID: WP_025269855.1
Location: 4119556..4119783 (228 bp)
Type: Others
Protein ID: WP_001254386.1
Location: 4114406..4114594 (189 bp)
Type: Others
Protein ID: WP_001299721.1
Location: 4117278..4117787 (510 bp)
Type: Others
Protein ID: WP_025269853.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CF61_RS284654110098..4110304+207WP_000275853.1hypothetical protein-
CF61_RS205954110330..4110869+540WP_000290839.1single-stranded DNA-binding protein-
CF61_RS206004110932..4111165+234WP_000005990.1DUF905 family protein-
CF61_RS206054111231..4113189+1959WP_025269850.1ParB/RepB/Spo0J family partition protein-
CF61_RS206104113244..4113678+435WP_001470779.1conjugation system SOS inhibitor PsiB-
CF61_RS206154113675..4114394+720WP_001276232.1plasmid SOS inhibition protein A-
CF61_RS282654114406..4114594-189WP_001299721.1hypothetical protein-
-4114406..4114630+225NuclAT_0--
-4114406..4114630+225NuclAT_0--
-4114406..4114630+225NuclAT_0--
-4114406..4114630+225NuclAT_0--
-4114563..4114628+66--Antitoxin
CF61_RS206254114674..4114832+159WP_001312861.1type I toxin-antitoxin system Hok family toxinToxin
CF61_RS284704115523..4115729+207WP_000547974.1hypothetical protein-
CF61_RS206404115754..4116041+288WP_000107535.1hypothetical protein-
CF61_RS206454116160..4116981+822WP_025269852.1DUF945 domain-containing protein-
CF61_RS206504117278..4117787-510WP_025269853.1transglycosylase SLT domain-containing protein-
CF61_RS206554118202..4118585+384WP_025269854.1relaxosome protein TraM-
CF61_RS206604118776..4119462+687WP_025269855.1PAS domain-containing protein-
CF61_RS206654119556..4119783+228WP_001254386.1conjugal transfer relaxosome protein TraY-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--4073654..411778744133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-48)


Sequences


Toxin        


Download         Length: 53 a.a.        Molecular weight: 6082.32 Da        Isoelectric Point: 9.2584

>T46314 WP_001312861.1 NZ_CP007391:4114674-4114832 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 159 bp

>T46314 NZ_CP007391:4114674-4114832 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 66 bp

>AT46314 NZ_CP007391:4114563-4114628 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBP11895


Antitoxin

Download structure file

References