Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4044423..4044681 Replicon chromosome
Accession NZ_CP007275
Organism Escherichia coli strain O18

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag NMECO18_RS20165 Protein ID WP_000809168.1
Coordinates 4044423..4044575 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4044624..4044681 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMECO18_RS20145 4039668..4040381 - 714 WP_001102393.1 acidic protein MsyB -
NMECO18_RS20150 4040407..4040811 - 405 WP_000843687.1 DUF2541 family protein -
NMECO18_RS20155 4041183..4043099 + 1917 WP_000516135.1 molecular chaperone DnaK -
NMECO18_RS20160 4043188..4044318 + 1131 WP_001118464.1 molecular chaperone DnaJ -
NMECO18_RS20165 4044423..4044575 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 4044624..4044681 + 58 - - Antitoxin
NMECO18_RS20170 4045187..4045948 + 762 WP_001274823.1 hypothetical protein -
NMECO18_RS20175 4045968..4047461 + 1494 WP_047335278.1 sulfatase-like hydrolase/transferase -
NMECO18_RS20180 4047590..4048849 + 1260 WP_000494924.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T46265 WP_000809168.1 NZ_CP007275:c4044575-4044423 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T46265 NZ_CP007275:c4044575-4044423 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT46265 NZ_CP007275:4044624-4044681 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References