Detailed information of TA system TA046201

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 19735..20432
• Replicon: plasmid unnamed
• Accession: NZ_CP007231
• Organism: Yersinia similis strain Y_sim_228

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: BF17_RS22520
• Protein ID: WP_025384517.1
• Coordinates: 19735..20031 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: BF17_RS22525
• Protein ID: WP_025384518.1
• Coordinates: 20034..20432 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BF17_RS25445	15188..15394	+	207	WP_025384508.1	hypothetical protein	-
BF17_RS25885	15678..15896	-	219	WP_197090733.1	hypothetical protein	-
BF17_RS22485	15875..16381	+	507	WP_025384510.1	antirestriction protein ArdA	-
BF17_RS22490	16425..16625	+	201	WP_025384511.1	hypothetical protein	-
BF17_RS22500	17559..17933	+	375	WP_025384513.1	hypothetical protein	-
BF17_RS22505	18005..18358	+	354	WP_025384514.1	DUF3085 domain-containing protein	-
BF17_RS22515	18794..19633	+	840	WP_048677757.1	DUF4942 domain-containing protein	-
BF17_RS22520	19735..20031	+	297	WP_025384517.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BF17_RS22525	20034..20432	+	399	WP_025384518.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BF17_RS22530	20835..21284	+	450	WP_048677753.1	antirestriction protein	-
BF17_RS22535	21431..21682	+	252	WP_012606366.1	hypothetical protein	-
BF17_RS22540	21888..22157	+	270	WP_025384520.1	hypothetical protein	-
BF17_RS22545	22521..22829	-	309	WP_025384521.1	hypothetical protein	-
BF17_RS22550	23102..23425	+	324	WP_025384522.1	ribbon-helix-helix protein, CopG family	-
BF17_RS22555	23422..25332	+	1911	WP_025384523.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..60687	60687

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11006.67 Da
• Isoelectric Point: 6.4441

>T46201 WP_025384517.1 NZ_CP007231:19735-20031 [Yersinia similis]
MEKRTPHCKLSRIRELVQQGEITATNSALMGAAELGLSFQDMCDAVLSLSAKDFYKSMTTYADHTVWQDVYRPELNCGDV
YLKLTVSDGVLVVSFKRL

Nucleotide

• Length: 297 bp

>T46201 NZ_CP007231:19735-20031 [Yersinia similis]
ATGGAAAAGCGCACGCCTCATTGCAAGCTATCCCGCATCAGGGAGTTAGTTCAACAAGGCGAGATAACCGCGACGAACAG
TGCATTAATGGGGGCTGCGGAACTCGGGCTGAGTTTTCAGGACATGTGTGATGCTGTTTTGTCGTTATCGGCTAAAGACT
TTTACAAAAGTATGACGACTTACGCCGATCATACGGTATGGCAAGACGTTTACCGCCCCGAGTTAAATTGCGGTGACGTT
TATCTAAAACTGACGGTTTCTGATGGCGTATTAGTTGTTTCGTTCAAGAGGTTATGA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14418.57 Da
• Isoelectric Point: 7.2650

>AT46201 WP_025384518.1 NZ_CP007231:20034-20432 [Yersinia similis]
MKCPVCGGAELFHDIRELSYTYKGESTIIANVEGDYCPACNEVIISKHDAARVSAAMLAFNKEVNAAIVSPLFIAEVRNK
LALSQREAGEIFGGGANAFSRYETGRAKPHLSTVKLLRVLDKHPDLLQEIRA

Nucleotide

• Length: 399 bp

>AT46201 NZ_CP007231:20034-20432 [Yersinia similis]
ATGAAATGTCCAGTATGCGGTGGAGCTGAATTGTTCCACGATATCCGTGAGTTGTCCTATACCTACAAGGGTGAGTCTAC
AATAATAGCGAATGTTGAAGGCGATTATTGTCCTGCCTGCAATGAGGTTATTATCAGTAAACATGATGCAGCGCGTGTCA
GTGCTGCTATGTTGGCCTTTAATAAAGAGGTCAACGCCGCCATAGTCTCCCCCTTATTTATTGCTGAGGTCAGAAATAAG
TTGGCGCTCTCACAACGAGAGGCTGGTGAAATATTTGGCGGGGGCGCGAATGCCTTTTCACGTTATGAAACGGGACGAGC
TAAGCCGCATCTGTCAACGGTGAAGCTGTTGCGTGTTCTTGATAAGCATCCTGATTTATTGCAGGAAATCCGCGCATAA