Detailed information of TA system TA046188

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 5028290..5028879
• Replicon: chromosome
• Accession: NZ_CP007221
• Organism: Xanthomonas oryzae pv. oryzicola strain CFBP7342

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A0C5V8F2
• Locus tag: BE73_RS22520
• Protein ID: WP_024712137.1
• Coordinates: 5028290..5028571 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BE73_RS22525
• Protein ID: WP_011260746.1
• Coordinates: 5028589..5028879 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BE73_RS22515	5025934..5028195	+	2262	WP_044751356.1	exodeoxyribonuclease V subunit alpha	-
BE73_RS22520	5028290..5028571	+	282	WP_024712137.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BE73_RS22525	5028589..5028879	+	291	WP_011260746.1	HigA family addiction module antidote protein	Antitoxin
BE73_RS22530	5029817..5031211	+	1395	WP_024712138.1	nucleoside hydrolase	-
BE73_RS22535	5031662..5031994	-	333	WP_011260743.1	hypothetical protein	-
BE73_RS22545	5032330..5032554	+	225	WP_044751358.1	hypothetical protein	-
BE73_RS22550	5032692..5033126	+	435	WP_071162385.1	PAAR domain-containing protein	-
BE73_RS22555	5033129..5033605	+	477	WP_024712141.1	DUF4123 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11107.88 Da
• Isoelectric Point: 10.5318

>T46188 WP_024712137.1 NZ_CP007221:5028290-5028571 [Xanthomonas oryzae pv. oryzicola]
IIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYNIRINDQWRICFRWM
EGDVVQVEIVDYH

Nucleotide

• Length: 282 bp

>T46188 NZ_CP007221:5028290-5028571 [Xanthomonas oryzae pv. oryzicola]
ATCATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCGCATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGGCGCGGCCAGTACAACATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10420.07 Da
• Isoelectric Point: 7.2040

>AT46188 WP_011260746.1 NZ_CP007221:5028589-5028879 [Xanthomonas oryzae pv. oryzicola]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT46188 NZ_CP007221:5028589-5028879 [Xanthomonas oryzae pv. oryzicola]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0C5V8F2