Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1818188..1818848 Replicon chromosome
Accession NZ_CP007215
Organism Kosakonia sacchari SP1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C813_RS31570 Protein ID WP_025263559.1
Coordinates 1818188..1818541 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C813_RS31575 Protein ID WP_017458421.1
Coordinates 1818546..1818848 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C813_RS31550 1813454..1814194 + 741 WP_017458426.1 adenosylcobinamide-GDP ribazoletransferase -
C813_RS31555 1814222..1815280 + 1059 WP_025263558.1 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase -
C813_RS31560 1815318..1815629 - 312 WP_017458424.1 helix-turn-helix domain-containing protein -
C813_RS31565 1815867..1817969 + 2103 WP_017458423.1 elongation factor G -
C813_RS31570 1818188..1818541 + 354 WP_025263559.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C813_RS31575 1818546..1818848 + 303 WP_017458421.1 helix-turn-helix transcriptional regulator Antitoxin
C813_RS31580 1818931..1819881 + 951 WP_017458420.1 L,D-transpeptidase -
C813_RS31585 1820024..1821049 + 1026 WP_017458419.1 LLM class flavin-dependent oxidoreductase -
C813_RS31590 1821236..1821712 + 477 WP_017458418.1 cold shock domain-containing protein -
C813_RS31595 1821717..1821917 + 201 WP_025263560.1 hypothetical protein -
C813_RS31600 1821952..1822491 + 540 WP_017458417.1 DUF2058 domain-containing protein -
C813_RS31605 1822529..1822774 + 246 Protein_1692 YmjA family protein -
C813_RS31610 1822871..1823380 - 510 WP_017458415.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13602.82 Da        Isoelectric Point: 9.7701

>T46172 WP_025263559.1 NZ_CP007215:1818188-1818541 [Kosakonia sacchari SP1]
VWQIIMTQTFEKWFDALGDNDRASVLAALMVLRVKGPQLPRPYADTVKGSRYNNMKELRIQSQGEPFRVFYAFDPQRVGI
LLCAGNKASHEKRFYDVMIQIADLELTHHLHKIKIKE

Download         Length: 354 bp

>T46172 NZ_CP007215:1818188-1818541 [Kosakonia sacchari SP1]
GTGTGGCAGATAATAATGACGCAGACGTTTGAAAAGTGGTTTGATGCACTGGGTGACAACGATCGCGCCAGTGTGCTGGC
GGCGCTGATGGTGCTCCGGGTTAAAGGTCCACAGCTACCAAGACCTTACGCGGATACAGTAAAAGGCTCGCGTTATAACA
ATATGAAAGAGTTGCGCATACAAAGCCAGGGCGAACCGTTTCGGGTTTTCTATGCCTTCGATCCGCAGCGCGTGGGAATA
TTGCTTTGCGCTGGCAACAAGGCGAGCCATGAAAAACGTTTTTACGATGTGATGATCCAGATTGCAGATCTGGAGCTAAC
GCACCATCTGCACAAGATTAAAATCAAGGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11236.03 Da        Isoelectric Point: 6.4719

>AT46172 WP_017458421.1 NZ_CP007215:1818546-1818848 [Kosakonia sacchari SP1]
MSKTLEQLIAEQKTDVVTAAQSLAQEMLLNIHLAELRERVQKTQIEMAQELGLKQPTVAVMEKQGRDIKLSTLKRYVEAT
GSKLRIDIELPDGSHYGFAL

Download         Length: 303 bp

>AT46172 NZ_CP007215:1818546-1818848 [Kosakonia sacchari SP1]
ATGAGCAAAACGCTGGAACAGCTAATTGCCGAACAAAAGACCGATGTCGTCACCGCTGCGCAGTCACTTGCGCAAGAGAT
GCTGCTCAACATCCACCTTGCCGAGCTGCGTGAGCGGGTACAAAAAACGCAGATCGAAATGGCGCAGGAGTTGGGGCTGA
AACAACCGACGGTAGCGGTGATGGAAAAGCAGGGGCGGGACATTAAACTTTCCACGCTGAAGCGCTACGTGGAAGCGACA
GGCAGCAAGCTACGCATTGATATTGAGCTGCCGGATGGCTCGCACTATGGCTTTGCGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References