Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2635856..2636379 Replicon chromosome
Accession NZ_CP007176
Organism Staphylococcus aureus USA300-ISMMS1

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag AZ30_RS13630 Protein ID WP_000074048.1
Coordinates 2635856..2636122 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag AZ30_RS13635 Protein ID WP_000587616.1
Coordinates 2636122..2636379 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZ30_RS13610 2631163..2632350 - 1188 WP_000026194.1 MFS transporter -
AZ30_RS13615 2632746..2633522 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
AZ30_RS13620 2633515..2634177 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
AZ30_RS13625 2634425..2635501 - 1077 WP_001076671.1 M42 family metallopeptidase -
AZ30_RS13630 2635856..2636122 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
AZ30_RS13635 2636122..2636379 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AZ30_RS13645 2636738..2637193 + 456 WP_000732082.1 DUF1307 domain-containing protein -
AZ30_RS13650 2637361..2638938 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
AZ30_RS13655 2639133..2639882 + 750 WP_000072444.1 hypothetical protein -
AZ30_RS13660 2640106..2641299 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T46151 WP_000074048.1 NZ_CP007176:c2636122-2635856 [Staphylococcus aureus USA300-ISMMS1]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T46151 NZ_CP007176:c2636122-2635856 [Staphylococcus aureus USA300-ISMMS1]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT46151 WP_000587616.1 NZ_CP007176:c2636379-2636122 [Staphylococcus aureus USA300-ISMMS1]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT46151 NZ_CP007176:c2636379-2636122 [Staphylococcus aureus USA300-ISMMS1]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References