Detailed information of TA system TA046149

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2604356..2604540
• Replicon: chromosome
• Accession: NZ_CP007176
• Organism: Staphylococcus aureus USA300-ISMMS1

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: -
• Locus tag: AZ30_RS13475
• Protein ID: WP_038410409.1
• Coordinates: 2604433..2604540 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2604356..2604416 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AZ30_RS13450	2599886..2600053	-	168	WP_001790576.1	hypothetical protein	-
AZ30_RS13460	2600284..2602017	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
AZ30_RS13465	2602042..2603805	-	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
-	2604356..2604416	+	61	-	-	Antitoxin
AZ30_RS13475	2604433..2604540	-	108	WP_038410409.1	type I toxin-antitoxin system Fst family toxin	Toxin
AZ30_RS13480	2604674..2605060	-	387	WP_000779358.1	flippase GtxA	-
AZ30_RS13485	2605328..2606470	+	1143	WP_001176863.1	glycerate kinase	-
AZ30_RS13490	2606530..2607189	+	660	WP_000831298.1	membrane protein	-
AZ30_RS13495	2607371..2608582	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
AZ30_RS13500	2608705..2609178	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3992.73 Da
• Isoelectric Point: 10.4997

>T46149 WP_038410409.1 NZ_CP007176:c2604540-2604433 [Staphylococcus aureus USA300-ISMMS1]
MFNLLINIMTSAISGCLVAFFAHWLRTHNNKKGDK

Nucleotide

• Length: 108 bp

>T46149 NZ_CP007176:c2604540-2604433 [Staphylococcus aureus USA300-ISMMS1]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCACAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT46149 NZ_CP007176:2604356-2604416 [Staphylococcus aureus USA300-ISMMS1]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Antitoxin