Detailed information of TA system TA046138

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2139631..2139930
• Replicon: chromosome
• Accession: NZ_CP007176
• Organism: Staphylococcus aureus USA300-ISMMS1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: AZ30_RS15770
• Protein ID: WP_011447039.1
• Coordinates: 2139754..2139930 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2139631..2139686 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AZ30_RS10845	2134962..2135222	+	261	WP_001791826.1	hypothetical protein	-
AZ30_RS10850	2135275..2135625	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AZ30_RS10855	2136310..2136759	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
AZ30_RS16115	2136854..2137189	-	336	Protein_2065	SH3 domain-containing protein	-
AZ30_RS10865	2137839..2138330	-	492	WP_000919350.1	staphylokinase	-
AZ30_RS10870	2138521..2139276	-	756	WP_000861038.1	CHAP domain-containing protein	-
AZ30_RS10875	2139288..2139542	-	255	WP_000611512.1	phage holin	-
AZ30_RS10880	2139594..2139701	+	108	WP_001791821.1	hypothetical protein	-
-	2139623..2139762	+	140	NuclAT_0	-	-
-	2139623..2139762	+	140	NuclAT_0	-	-
-	2139623..2139762	+	140	NuclAT_0	-	-
-	2139623..2139762	+	140	NuclAT_0	-	-
-	2139631..2139686	+	56	-	-	Antitoxin
AZ30_RS15770	2139754..2139930	-	177	WP_011447039.1	putative holin-like toxin	Toxin
AZ30_RS10890	2140080..2140376	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
AZ30_RS10895	2140434..2140721	-	288	WP_001040261.1	hypothetical protein	-
AZ30_RS10900	2140768..2140920	-	153	WP_001153681.1	hypothetical protein	-
AZ30_RS10905	2140910..2144695	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2135275..2194243	58968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T46138 WP_011447039.1 NZ_CP007176:c2139930-2139754 [Staphylococcus aureus USA300-ISMMS1]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T46138 NZ_CP007176:c2139930-2139754 [Staphylococcus aureus USA300-ISMMS1]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT46138 NZ_CP007176:2139631-2139686 [Staphylococcus aureus USA300-ISMMS1]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin