Detailed information of TA system TA046135

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1935632..1935814
• Replicon: chromosome
• Accession: NZ_CP007176
• Organism: Staphylococcus aureus USA300-ISMMS1

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: AZ30_RS16085
• Protein ID: WP_001801861.1
• Coordinates: 1935632..1935727 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1935755..1935814 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AZ30_RS09565	1931292..1931918	+	627	Protein_1841	hypothetical protein	-
AZ30_RS09570	1931959..1932303	+	345	WP_000627551.1	DUF3969 family protein	-
AZ30_RS09575	1932401..1932952	+	552	WP_000414205.1	hypothetical protein	-
AZ30_RS09580	1933170..1933811	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
AZ30_RS09585	1933925..1934110	-	186	WP_000809857.1	hypothetical protein	-
AZ30_RS09590	1934112..1934288	-	177	WP_000375476.1	hypothetical protein	-
AZ30_RS09595	1934299..1934682	-	384	WP_000070811.1	hypothetical protein	-
AZ30_RS09605	1935286..1935429	-	144	WP_001549059.1	transposase	-
AZ30_RS16085	1935632..1935727	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1935755..1935814	-	60	-	-	Antitoxin
AZ30_RS09610	1935850..1935951	+	102	WP_001791893.1	hypothetical protein	-
AZ30_RS15685	1935929..1936105	-	177	Protein_1851	transposase	-
AZ30_RS09615	1936299..1936676	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T46135 WP_001801861.1 NZ_CP007176:1935632-1935727 [Staphylococcus aureus USA300-ISMMS1]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T46135 NZ_CP007176:1935632-1935727 [Staphylococcus aureus USA300-ISMMS1]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT46135 NZ_CP007176:c1935814-1935755 [Staphylococcus aureus USA300-ISMMS1]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin