Detailed information of TA system TA046127

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 334929..335518
• Replicon: chromosome
• Accession: NZ_CP007166
• Organism: Xanthomonas oryzae pv. oryzae PXO86

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A8E2YMU3
• Locus tag: AZ54_RS01460
• Protein ID: WP_011260747.1
• Coordinates: 334929..335210 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AZ54_RS01465
• Protein ID: WP_011260746.1
• Coordinates: 335228..335518 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AZ54_RS01455	332582..334834	+	2253	WP_044756263.1	exodeoxyribonuclease V subunit alpha	-
AZ54_RS01460	334929..335210	+	282	WP_011260747.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AZ54_RS01465	335228..335518	+	291	WP_011260746.1	HigA family addiction module antidote protein	Antitoxin
AZ54_RS01470	336457..337851	+	1395	WP_011260745.1	nucleoside hydrolase	-
AZ54_RS01475	338301..338633	-	333	WP_011260743.1	hypothetical protein	-
AZ54_RS01485	338969..339193	+	225	WP_044756265.1	hypothetical protein	-
AZ54_RS01490	339331..339765	+	435	WP_011260742.1	PAAR domain-containing protein	-
AZ54_RS01495	339768..340244	+	477	WP_011260741.1	DUF4123 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11038.77 Da
• Isoelectric Point: 10.2139

>T46127 WP_011260747.1 NZ_CP007166:334929-335210 [Xanthomonas oryzae pv. oryzae PXO86]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQQRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Nucleotide

• Length: 282 bp

>T46127 NZ_CP007166:334929-335210 [Xanthomonas oryzae pv. oryzae PXO86]
GTGATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCGCATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCAGCGCGGCCAGTACAGCATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10420.07 Da
• Isoelectric Point: 7.2040

>AT46127 WP_011260746.1 NZ_CP007166:335228-335518 [Xanthomonas oryzae pv. oryzae PXO86]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT46127 NZ_CP007166:335228-335518 [Xanthomonas oryzae pv. oryzae PXO86]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA