Detailed information of TA system TA046117

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2522603..2523284
• Replicon: chromosome
• Accession: NZ_CP007147
• Organism: Pseudomonas aeruginosa YL84

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AI22_RS11550
• Protein ID: WP_015503432.1
• Coordinates: 2522603..2522968 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AI22_RS11555
• Protein ID: WP_016561576.1
• Coordinates: 2522961..2523284 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AI22_RS11520	2518608..2519042	-	435	WP_016253806.1	RidA family protein	-
AI22_RS11525	2519263..2520216	+	954	WP_003085661.1	LysR family transcriptional regulator	-
AI22_RS11530	2520189..2521073	-	885	WP_016253805.1	LysR family transcriptional regulator	-
AI22_RS11535	2521174..2521599	+	426	WP_003114206.1	ring-cleaving dioxygenase	-
AI22_RS11540	2521618..2521890	-	273	WP_003085667.1	hypothetical protein	-
AI22_RS11545	2522097..2522339	+	243	WP_043884955.1	hypothetical protein	-
AI22_RS11550	2522603..2522968	+	366	WP_015503432.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AI22_RS11555	2522961..2523284	+	324	WP_016561576.1	XRE family transcriptional regulator	Antitoxin
AI22_RS30685	2523400..2523519	-	120	Protein_2279	IS5/IS1182 family transposase	-
AI22_RS11565	2523574..2523906	+	333	WP_016561578.1	hypothetical protein	-
AI22_RS29915	2523906..2524181	+	276	WP_004353146.1	hypothetical protein	-
AI22_RS29920	2524356..2524898	+	543	WP_019396018.1	tyrosine-type recombinase/integrase	-
AI22_RS29925	2524913..2525140	-	228	WP_014603215.1	hypothetical protein	-
AI22_RS11575	2525743..2526621	-	879	WP_003163191.1	hypothetical protein	-
AI22_RS11580	2526709..2527392	+	684	WP_003120766.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-63)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13798.14 Da
• Isoelectric Point: 4.8219

>T46117 WP_015503432.1 NZ_CP007147:2522603-2522968 [Pseudomonas aeruginosa YL84]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Nucleotide

• Length: 366 bp

>T46117 NZ_CP007147:2522603-2522968 [Pseudomonas aeruginosa YL84]
GTGGCGTGGGATATCGAGTACACCGACGAGTTCGGTGATTGGTGGGGTTCTCTGTCCGAGGATGAGCAGGAGTCGCTAGC
TGTGACGGTTCGCTTGCTTGAGGAGCGGGGGCCATCCTTGGGGCACCCCCACAGCAGCGGCATCAATGGCTCCCGCCCTG
GCCATATGAGAGAGCTACGGACTCAACACGGCGGGCGACCTTTCCGAACGCTTTACGCGTTTGACCCCAGACGCTCCGCG
ATACTGCCGATCGGTGGCGACAAGACTGGCGATGATCGTTGGTACGAATTGAACGTGCCCATTGCCGACCGCCTCCATGA
CGAACACTTGCACCAGCTCCGTGAGGAGGGACTGATCGATGGCTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11903.72 Da
• Isoelectric Point: 5.8900

>AT46117 WP_016561576.1 NZ_CP007147:2522961-2523284 [Pseudomonas aeruginosa YL84]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQSRGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Nucleotide

• Length: 324 bp

>AT46117 NZ_CP007147:2522961-2523284 [Pseudomonas aeruginosa YL84]
ATGGCTAAGAAATTCTCCGACCTTCGGGCGCAAATGTCGCCTGAGGCACAGGCCCGCGTCGAGGCCAAGGCCCAGGAACT
GTTGGCTGAAATGCCCCTGAATGAGTTGCGCCAGTCTAGAGGCTTGTCGCAGAAGATGCTGTCTGAAGTGCTGCAGGTGC
AGCAGCCGGCAATTGCCAAGATGGAGCGGCGTACGGATATGTACATCTCCACCTTGCGCAGCCACATCGAAGCCATGGGC
GGCCAGCTGGAAGTGATTGCACGCTTCCCGGATGGTGCGGTGAAAATCAGCAACTTCGCGGATATCGAAGAGGCGGGCGC
CTAA