Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1077348..1077573 Replicon chromosome
Accession NZ_CP007133
Organism Escherichia coli O145:H28 str. RM12761

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag ECRM12761_RS05190 Protein ID WP_000813254.1
Coordinates 1077418..1077573 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 1077348..1077406 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECRM12761_RS05165 1072608..1073714 + 1107 WP_025380294.1 hypothetical protein -
ECRM12761_RS05170 1073721..1074467 + 747 WP_000788759.1 ATP-binding protein -
ECRM12761_RS05175 1074489..1075259 + 771 WP_000451007.1 DUF1627 domain-containing protein -
ECRM12761_RS05180 1075275..1075688 + 414 WP_001151233.1 DUF977 family protein -
ECRM12761_RS05185 1076040..1076813 - 774 WP_000160654.1 alpha/beta hydrolase -
- 1077348..1077406 - 59 - - Antitoxin
ECRM12761_RS05190 1077418..1077573 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
ECRM12761_RS31170 1077741..1078019 + 279 WP_001341388.1 hypothetical protein -
ECRM12761_RS05200 1078021..1079070 + 1050 WP_025380295.1 DUF968 domain-containing protein -
ECRM12761_RS05205 1079083..1079454 + 372 WP_001217436.1 RusA family crossover junction endodeoxyribonuclease -
ECRM12761_RS05210 1079444..1079815 + 372 WP_000090265.1 antitermination protein -
ECRM12761_RS05215 1079967..1080785 + 819 WP_000265267.1 CPBP family intramembrane metalloprotease -
ECRM12761_RS05220 1081072..1081269 + 198 WP_000917737.1 hypothetical protein -
ECRM12761_RS05225 1081407..1082120 + 714 WP_000261909.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T46037 WP_000813254.1 NZ_CP007133:1077418-1077573 [Escherichia coli O145:H28 str. RM12761]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T46037 NZ_CP007133:1077418-1077573 [Escherichia coli O145:H28 str. RM12761]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT46037 NZ_CP007133:c1077406-1077348 [Escherichia coli O145:H28 str. RM12761]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References