Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1548235..1548799 Replicon chromosome
Accession NZ_CP007122
Organism Lactobacillus paracasei N1115

Toxin (Protein)


Gene name yafQ Uniprot ID C2FG57
Locus tag AF91_RS07430 Protein ID WP_003661092.1
Coordinates 1548235..1548537 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A8E0I752
Locus tag AF91_RS07435 Protein ID WP_016365698.1
Coordinates 1548530..1548799 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AF91_RS07415 1543918..1544355 + 438 WP_003661085.1 hypothetical protein -
AF91_RS07420 1544530..1546707 - 2178 WP_016383421.1 RNA-binding transcriptional accessory protein -
AF91_RS07425 1546943..1547635 - 693 WP_003661089.1 hypothetical protein -
AF91_RS07430 1548235..1548537 - 303 WP_003661092.1 type II toxin-antitoxin system YafQ family toxin Toxin
AF91_RS07435 1548530..1548799 - 270 WP_016365698.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AF91_RS07440 1549173..1549826 - 654 WP_003570049.1 GNAT family N-acetyltransferase -
AF91_RS07445 1549871..1550686 - 816 WP_003661098.1 DUF2399 domain-containing protein -
AF91_RS15930 1550711..1551334 - 624 WP_079351422.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11383.23 Da        Isoelectric Point: 10.4225

>T46030 WP_003661092.1 NZ_CP007122:c1548537-1548235 [Lactobacillus paracasei N1115]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELHVDGPRGGWLLIYKIK
QQDLILTLVRTGSHHNLLGK

Download         Length: 303 bp

>T46030 NZ_CP007122:c1548537-1548235 [Lactobacillus paracasei N1115]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCTGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCTT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTACATGTTGACGGCCCTCGTGGCGGCTGGTTGCTAATCTATAAAATTAAG
CAGCAAGATCTTATTTTAACCCTAGTTAGAACCGGATCTCATCATAACCTTCTGGGTAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9996.71 Da        Isoelectric Point: 7.2026

>AT46030 WP_016365698.1 NZ_CP007122:c1548799-1548530 [Lactobacillus paracasei N1115]
MAATKKETRLNIRIDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT46030 NZ_CP007122:c1548799-1548530 [Lactobacillus paracasei N1115]
ATGGCAGCCACAAAGAAAGAAACTCGCTTGAATATTCGTATTGATCCTGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACGATGTTCATGACGAAAATGGTGAAGGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACACCT
GATGACATGTGGAGAGACTTGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References