Detailed information of TA system TA045963

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1379480..1379982
• Replicon: chromosome
• Accession: NZ_CP007030
• Organism: Thiomicrospira aerophila AL3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: W0DSA6
• Locus tag: THIAE_RS06720
• Protein ID: WP_006461053.1
• Coordinates: 1379480..1379734 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: W0DXB2
• Locus tag: THIAE_RS06725
• Protein ID: WP_006461054.1
• Coordinates: 1379725..1379982 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THIAE_RS06710	1374816..1375370	-	555	WP_006461051.1	hypothetical protein	-
THIAE_RS06715	1375531..1379466	-	3936	WP_006461052.1	ATP-dependent RNA helicase HrpA	-
THIAE_RS06720	1379480..1379734	-	255	WP_006461053.1	Txe/YoeB family addiction module toxin	Toxin
THIAE_RS06725	1379725..1379982	-	258	WP_006461054.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
THIAE_RS06730	1380145..1380681	-	537	WP_006461055.1	DUF3087 domain-containing protein	-
THIAE_RS06735	1380699..1381124	-	426	WP_006461056.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
THIAE_RS06740	1381201..1381908	+	708	WP_006461057.1	DNA polymerase III subunit epsilon	-
THIAE_RS06745	1381924..1382772	-	849	WP_006461058.1	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	-
THIAE_RS06765	1383268..1384554	-	1287	WP_006461059.1	diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10358.87 Da
• Isoelectric Point: 9.8763

>T45963 WP_006461053.1 NZ_CP007030:c1379734-1379480 [Thiomicrospira aerophila AL3]
MRLIFSEHAWSDYLYWQTQDKKTLKKINDLIHEIQRTPFEGRGKPETLKHALSSYWSRRINQEHRIVYKLVENDLLIAQL
RYHY

Nucleotide

• Length: 255 bp

>T45963 NZ_CP007030:c1379734-1379480 [Thiomicrospira aerophila AL3]
ATGCGATTAATATTTTCAGAGCATGCTTGGTCTGATTATCTTTATTGGCAAACGCAAGACAAAAAGACCCTCAAGAAAAT
CAATGATCTGATCCATGAAATTCAACGAACGCCTTTTGAAGGGCGAGGTAAACCAGAAACGCTTAAACATGCATTAAGCA
GTTATTGGTCGCGCCGTATTAACCAAGAGCACCGCATTGTTTACAAGCTGGTGGAGAATGATCTTCTCATTGCTCAACTT
CGCTATCATTACTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9651.88 Da
• Isoelectric Point: 5.0744

>AT45963 WP_006461054.1 NZ_CP007030:c1379982-1379725 [Thiomicrospira aerophila AL3]
MQAVTYSWARNHLAESINQVCDNHEAMVITKKNDRAAVLMSLEDYQALEETAYLLRSPKNAKRLMDSIHELESGQSQARA
LVECD

Nucleotide

• Length: 258 bp

>AT45963 NZ_CP007030:c1379982-1379725 [Thiomicrospira aerophila AL3]
ATGCAAGCTGTTACCTATTCTTGGGCGCGCAACCATTTAGCGGAAAGTATTAACCAGGTGTGTGATAACCATGAAGCGAT
GGTGATCACCAAAAAAAATGATCGTGCAGCCGTTTTGATGTCACTTGAGGACTATCAAGCGCTAGAAGAAACCGCTTACT
TGCTGCGTAGCCCGAAAAATGCCAAGCGTTTAATGGATTCGATCCATGAGCTTGAAAGTGGACAGAGTCAAGCGCGGGCA
TTGGTTGAATGCGATTAA

Structures

Toxin

• AlphaFold DB: W0DSA6

Antitoxin

• AlphaFold DB: W0DXB2