Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1076019..1076629 Replicon chromosome
Accession NZ_CP007029
Organism Thioalkalivibrio paradoxus ARh

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag THITH_RS17610 Protein ID WP_084222618.1
Coordinates 1076019..1076300 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag THITH_RS17615 Protein ID WP_006748811.1
Coordinates 1076315..1076629 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THITH_RS04945 1071600..1072709 + 1110 WP_006748814.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
THITH_RS04950 1072864..1074105 - 1242 WP_025367289.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
THITH_RS18460 1074502..1075014 + 513 WP_156925489.1 hypothetical protein -
THITH_RS04955 1075091..1075891 + 801 WP_006748812.1 hypothetical protein -
THITH_RS17610 1076019..1076300 + 282 WP_084222618.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
THITH_RS17615 1076315..1076629 + 315 WP_006748811.1 HigA family addiction module antidote protein Antitoxin
THITH_RS04965 1076774..1076995 + 222 WP_006748810.1 addiction module protein -
THITH_RS04970 1076995..1077291 + 297 WP_006748809.1 type II toxin-antitoxin system RelE/ParE family toxin -
THITH_RS17625 1077643..1077873 + 231 WP_006748807.1 hypothetical protein -
THITH_RS18700 1078607..1078807 + 201 WP_198019495.1 DUF4258 domain-containing protein -
THITH_RS17635 1078804..1079064 + 261 WP_084222619.1 YgiT-type zinc finger protein -
THITH_RS17645 1079958..1080173 - 216 WP_198019471.1 type II toxin-antitoxin system RelE/ParE family toxin -
THITH_RS18705 1080158..1080298 - 141 WP_198019522.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-74)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10652.05 Da        Isoelectric Point: 9.0530

>T45949 WP_084222618.1 NZ_CP007029:1076019-1076300 [Thioalkalivibrio paradoxus ARh 1]
MIKTFADKRTQGLYSKGKSKKFPADVAPRAARKLEYVNLAERLEDLKAPPGNRLHALSGNRQGQHAISINDQWRICFRFE
DGDAYEVEVCDYH

Download         Length: 282 bp

>T45949 NZ_CP007029:1076019-1076300 [Thioalkalivibrio paradoxus ARh 1]
ATGATCAAAACATTCGCGGATAAACGAACTCAGGGGCTCTACTCCAAAGGTAAGTCAAAGAAATTTCCTGCGGATGTCGC
GCCGAGAGCCGCCAGAAAGCTCGAATATGTCAACCTGGCTGAACGGTTGGAGGATTTGAAGGCGCCGCCCGGTAATCGCC
TTCACGCGCTATCGGGAAACAGGCAGGGACAACACGCGATTTCAATAAACGATCAGTGGCGCATTTGCTTTCGATTTGAG
GATGGTGATGCGTATGAGGTCGAAGTGTGTGACTACCACTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11605.25 Da        Isoelectric Point: 7.0154

>AT45949 WP_006748811.1 NZ_CP007029:1076315-1076629 [Thioalkalivibrio paradoxus ARh 1]
MAIPNTSGMQRKPTHPGEMLREDFLPDYGLTVAGLAESLGVSRQSVNELLRERRAVSPEMALRLARLFGNSPEFWLNAQR
SVDLWTAAQSVKEEVDRIKPLNAA

Download         Length: 315 bp

>AT45949 NZ_CP007029:1076315-1076629 [Thioalkalivibrio paradoxus ARh 1]
ATGGCTATACCTAATACATCGGGCATGCAGCGCAAGCCGACTCACCCTGGCGAAATGCTGAGAGAGGATTTCCTACCGGA
CTATGGCCTGACCGTTGCGGGGTTGGCAGAGTCTCTGGGTGTCTCTCGCCAGTCAGTCAATGAGTTGCTGCGCGAGCGCC
GTGCTGTCAGTCCTGAAATGGCGCTCCGGCTTGCTCGCTTGTTTGGTAACTCTCCGGAGTTCTGGCTGAATGCACAGAGA
TCCGTTGATCTTTGGACGGCAGCCCAGTCGGTCAAGGAGGAAGTGGATCGGATCAAGCCGCTAAATGCTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References