Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2975974..2976622 Replicon chromosome
Accession NZ_CP007027
Organism Mycobacterium tuberculosis H37RvSiena

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag Y980_RS14065 Protein ID WP_003899414.1
Coordinates 2975974..2976297 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag Y980_RS14070 Protein ID WP_003899415.1
Coordinates 2976377..2976622 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y980_RS14045 2971548..2972809 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
Y980_RS14050 2973183..2974622 - 1440 WP_009935349.1 phage major capsid protein -
Y980_RS14055 2974630..2975163 - 534 WP_003899412.1 HK97 family phage prohead protease -
Y980_RS21625 2975316..2975807 - 492 WP_003900541.1 phage terminase small subunit P27 family -
Y980_RS14065 2975974..2976297 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
Y980_RS14070 2976377..2976622 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
Y980_RS14075 2976619..2978046 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
Y980_RS14080 2978048..2978440 - 393 WP_003899417.1 DUF2742 domain-containing protein -
Y980_RS14085 2978437..2978697 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
Y980_RS14090 2978714..2979076 - 363 WP_003900543.1 hypothetical protein -
Y980_RS14095 2979079..2980206 - 1128 WP_003899420.1 site-specific integrase -
Y980_RS14100 2980351..2980578 - 228 WP_003899421.1 hypothetical protein -
Y980_RS21630 2980575..2980964 - 390 WP_003899422.1 hypothetical protein -
Y980_RS14105 2980870..2981142 + 273 WP_003900544.1 hypothetical protein -
Y980_RS14110 2981241..2981474 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2969939..2980206 10267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T45926 WP_003899414.1 NZ_CP007027:c2976297-2975974 [Mycobacterium tuberculosis H37RvSiena]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T45926 NZ_CP007027:c2976297-2975974 [Mycobacterium tuberculosis H37RvSiena]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT45926 WP_003899415.1 NZ_CP007027:c2976622-2976377 [Mycobacterium tuberculosis H37RvSiena]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT45926 NZ_CP007027:c2976622-2976377 [Mycobacterium tuberculosis H37RvSiena]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References